Surrogate Tissue Analysis (eBook, ePUB)

Genomic, Proteomic, and Metabolomic Approaches
Redaktion: Burczynski, Michael E.; Rockett, John C.

• Format: ePub

Produktbeschreibung

Both an introduction and a fundamental reference, this book explores how to apply genomic, proteomic, and metabolomic technologies to surrogate tissue analysis. It reviews fundamental analytical issues and actual initial results generated using these technologies. The book covers transcriptional profiling (genomics), protein profiling (proteomics), methylation profiling (epigenomics), metabolite profiling (metabolomics) and additional biomarker identification methods that can be applied to surrogate tissues. This book is useful to researchers and scientists interested in applying novel methodologies for identifying biomarkers in the fields of pharmacology, toxicology, and medicine.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Erscheinungstermin: 10. November 2005
• Englisch
• ISBN-13: 9781040168264
• Artikelnr.: 73207522

Autorenporträt

Michael E. Burczynski, John C. Rockett

Inhaltsangabe

INTRODUCTION TO SURROGATE TISSUE ANALYSIS. Introduction to Surrogate Tissue
Analysis. GENOMIC APPROACHES. Impact of Sample Handling and Preparation on
Gene Signatures as Exemplified for Transcriptome Analysis of Peripheral
Blood. Blood Genomic Fingerprints of Brain Diseases. Transcriptional
Profiling of Peripheral Blood in Oncology. Blood-Derived Transcriptomic
Profiles as a Means to Monitor Levels of Toxicant Exposure and the Effects
of Toxicants on Inaccessible Target Tissues. Spermatozoal RNAs as Surrogate
Markers of Paternal Exposure. PROTEOMIC APPROACHES. Proteomic Analysis of
Surrogate Tissues: Mass Spectrometry-Based Profiling of the Circulatory
Proteome for Cancer Detection and Stratification. Lymphocyte Integrins:
Potential Surrogate Biomarkers for Evaluation of Endometrial Receptivity.
Nipple Aspirate Fluid to Diagnose Breast Cancer and Monitor Response to
Treatment. METABOLOMICS AND OTHER APPROACHES. Metabonomics: Metabolic
Profiling and Pattern Recognition Analysis of Body Fluids and Tissues for
Characterization of Drug Toxicity and Disease Diagnosis. Comprehensive
Metabolomic Profiling of Serum and Cerebrospinal Fluid: Understanding
Disease, Human Variability, and Toxicity. Lipidomic Analysis of Plasma and
Tissues: Lipid-Derived Mediators of Inflammation and Markers of Disease.
Molecular Detection and Characterization of Circulating Tumor Cells and
Micrometastases in Solid Tumors. Methylation Profiling of Tumor Cells and
Tumor DNA in Blood, Urine, and Body Fluids for Cancer Detection and
Monitoring. FUTURE CONSIDERATIONS FOR SURROGATE TISSUE PROFILING.
Regulatory and Technical Challenges in Incorporating Surrogate Tissue
Profiling Strategies into Clinical Development Programs. Considerations in
the Economic Assessment of the Value of Molecular Profiling. The Impact and
Challenges of Pan-Omic Approaches in Pharmaceutical Discovery and
Development. Current and Future Aspects of Surrogate Tissue Analysis.
References.