Marco Brito-Arias

Synthesis and Characterization of Glycosides (eBook, PDF)

• Format: PDF

Produktbeschreibung

This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates.

Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control.

A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials.

The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.

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Produktdetails

• Verlag: Springer Nature Switzerland
• Seitenzahl: 530
• Erscheinungstermin: 22. April 2022
• Englisch
• ISBN-13: 9783030978549
• Artikelnr.: 63873826

Autorenporträt

Marco Brito-Arias is at the National Polytechnic Institute in Mexico.

Inhaltsangabe

Introduction.- O-Glycoside Formation.- N-glycosides.- Nucleotide Mimetics.- C-glycosides.- Glycoconjugates.- Hydrolysis of Glycosides.- Nuclear Magnetic Resonance of Glycosides.- X-Ray Diffraction of Glycosides.- Mass Spectrometry of Glycosides.- Docking studies of Glycosides.- Index.

Rezensionen

From the reviews: "Brito-Arias ... provides an overview of the structures and synthetic preparations of O-, N-, and C-glycosides, as well as discussion of the conformational features and biological function of selected examples. ... The organization of the book provides a ready resource for researchers seeking information. Indeed, the references to published synthetic methodology or analytical data included at the end of each chapter will be useful for researchers seeking additional information or details on a specific topic. ... Summing Up: Recommended. Graduate students through professionals." (P. W. Baures, CHOICE, Vol. 44 (11), July, 2007)