El Sayed H. El Ashry, Ahmed El Nemr

Synthesis of Naturally Occurring Nitrogen Heterocycles from Carbohydrates (eBook, PDF)

• Format: PDF

Produktbeschreibung

Carbohydrates are widely distributed in nature and widely available, and so are considered as a promising feedstock for the preparation of many organic chemical compounds. They are particularly useful in the preparation of nitrogen heterocycles because of their related structural characteristics and easy availability. Synthesis of Naturally Occurring Nitrogen Heterocycles from Carbohydrates will review the recent literature dealing with use of carbohydrates as raw materials in the synthesis of these materials. The text contains six chapters arranged according to the complexity of the heterocyclic compounds discussed, ranging from five to seven membered rings and from single to multiple fused rings. The book provides a detailed discussion of the various synthetic approaches to these compounds, using carbohydrate starting materials, and does not merely reference synthetic methodology but attempts to give as much detail as possible on the actual experimental conditions used, in such a way that the chemist can use the information directly to design a multi-step synthesis. It discusses the different approaches to the synthesis of a wide range of naturally occurring nitrogen heterocycles in a format that enables the reader to make comparisons and decisions on whether to use a certain procedure, to modify it, or to devise a new synthetic methodology.

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Produktdetails

• Verlag: Jossey-Bass
• Seitenzahl: 464
• Erscheinungstermin: 5. September 2008
• Englisch
• ISBN-13: 9781405144797
• Artikelnr.: 38280526

Autorenporträt

Professor El Sayed H. El Ashry1 Dr. Ahmed El Nemr 2 1 Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt. 2 Environmental Division, National Institute of Oceanography and Fisheries, Kayet Bay, Alexandria, Egypt.

Inhaltsangabe

Chapter 1 Five Membered Nitrogen Heterocycles.
1.1 Hydroxymethylpyrrolidines.
2-Hydroxymethyl-pyrrolidines.
Dihydro-2-hydroxymethylpyrrole (Nectrisine).
2,5-Dihydroxymethyl-pyrrolidines.
1.2 2-Carboxypyrrolidines.
Hydroxyprolines.
Bulgecins.
1.3 2-Aralkyl pyrrolidines.
Anisomycin.
Preussin.
1.4 2-Aryl pyrrolidines.
Codonopsinine and Codonopsine.
1.5 Miscellaneous.
Detoxins.
Gualamycin.
Lactacystin.
Chapter 2 Five Membered Heterocycles with two Heteroatoms.
2.1 Hydantocidin.
2.2 Bleomycin.
2.3 Calyculins.
2.4 Acivicin.
2.5 Bengazole.
Chapter 3 Six Membered Nitrogen Heterocycles.
3.1 Hydroxymethylpiperidines.
Nojirimycin.
Mannojirimycin.
Galactonojirimycin.
Fagomine.
Homojirimycins.
3.2 Miscellaneous substituted piperidines.
2,6-Disubstituted-3-hydroxypiperidines.
Hydroxylated pipicolic acid.
Sesbanimide.
Siastatin.
Meroquinene.
Pyridyl of pyridomycin.
Chapter 4 Seven Membered Nitrogen Heterocycles.
4.1 Bengamides.
4.2 Liposidomycins.
Chapter 5 Fused Nitrogen Heterocycles.
5.1 3:5-Fused Heterocycles.
Azinomycins.
5.2 4:5-Fused Heterocycles.
b-Lactams.
5.3 5:5-Fused Heterocycles.
Polyhydroxypyrrolizidines.
Trehazolin.
Allosamidin.
Biotin.
5.4 5:6-Fused Heterocycles.
Hydroxylated indolizidines.
Castanospermine.
Swainsonine.
Lentiginosine.
Slaframine.
Miscellaneous.
Kifunensine.
Nagastatin.
Calystegines.
Mesembrine.
Streptolidine.
55 6:6-Fused Heterocycles.
Hydroxylated Quinuclidines.
Biopterins.
Isoquinolines.
Calycotomine.
Decumbenosine.
Laudanosine and glaucine.
Chapter 6 Multi-fused heterocycles.
6.1 Indoloquinolizidines.
Xylopinine.
Antirhine.
Allo-Yohimbane.
Ajmalicine.
6.2 Indolocarbazole Alkaloids.
6.3 Phenanthridone alkaloids.
6.4 Ecteinascidins

Rezensionen

"The book is well organised and consists of 6 chapters, each ofwhich is devoted to a particular class of nitrogen heterocycles ....The book provides the reader with a wealth of detail on eachsynthesis, with the schemes "supported" by as much detail as couldbe expected on the experimental conditions used. Overall the bookis a valuable source of information for those involved in thesynthesis of nitrogen heterocycles and with a wealth of informationand good indexes" [This book is] Recommended if you are involved inthe field." Organic Process Research and DevelopmentJournal

"The authors have done a wonderful job of collating and makingsense of this diverse area of chemical literature. In summary, thisis a superb book. I am unlikely to read whole chapters in a singlesitting, but I will be browsing if for years to come, learningsomething new every time. Everyone who is interested in thesynthesis of nitrogen heterocycles should have access to thisbook." Mark Elliot , Lecturer in Organic Chemistry at the School ofChemistry, Cardiff University, UK

"The volume represents an enormous amount of synthetic work thatis very carefully reviewed on more than 420 pages."
Synthesis