Synthetic Glycomes (eBook, PDF)

Redaktion: Guan, Wanyi; Wang, Peng George; Li, Lei

• Format: PDF

Produktbeschreibung

Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, enzymatic and chemo-enzymatic ones have been developed to make libraries of structurally defined complex glycans available. The glycans provided by these techniques combined with high-throughput glycoarray techniques have broadened and deepened our understanding about functional glycomics. The aim of this book is to provide a comprehensive review of the current state of the synthetic glycome and a brief introduction of the application of the synthetic glycome in glycoarray assay. Accordingly, synthetic strategies toward generating glycans with comprehensive structures as well as the glycoarrays to unveil the glycan functions are described in this book.

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Produktdetails

• Verlag: Royal Society of Chemistry
• Seitenzahl: 469
• Erscheinungstermin: 8. April 2019
• Englisch
• ISBN-13: 9781788016575
• Artikelnr.: 56649009

Inhaltsangabe

Introduction: Glycome and the Glyco-toolbox
Methodologies in Chemical Syntheses of Carbohydrates
Synthetically Useful Glycosyltransferases for the Access of Mammalian Glycomes
Chemical Synthesis of N-Glycans
Chemoenzymatic Synthesis of N-glycans
Chemoenzymatic Synthesis of a-Dystroglycan O-Mannose Glycans
Chemical Synthesis of Glycopeptides and Glycoproteins
Synthesis of Chondroitin Sulfate Oligosaccharides and Chondroitin Sulfate Glycopeptides
Chemoenzymatic Synthesis of Heparan Sulfate and Heparin
Synthesis of Glycosphingolipids (GSLs)
Enzymatic and Chemoenzymatic Synthesis of Human Milk Oligosaccharides (HMOS)
Synthesis of Marine Polysaccharides/Oligosaccharides and Their Derivatives
Glycan Production by Bacterial Fermentation
Solid-phase Glycan Synthesis
Reverse Synthesis of Natural Glycans
Novel Technologies for Quantitative O-glycomics and Amplification/Preparation of Cellular O-glycans
Current Stage of Commercially Available Glycans to Support Realization of Biologic Drugs
Glycan Microarrays with Semi-synthetic Neoglycoconjugate Probes in Understanding Glycobiology
Current Stage of Commercial Glycan Microarrays