Systems Biology (eBook, PDF)

Redaktion: Maly, Ivan V.

• Format: PDF

Produktbeschreibung

The rapidly developing methods of systems biology can help investigators to make inference and predictions from their data that intuition alone would not discern; however, the difficulty lies in the broad knowledge of mathematics and engineering that seems to be required to even evaluate the applicability of the methods to the problem at hand. In Systems Biology, scientists who possess that mathematical knowledge and have applied it effectively to various biological problems contribute methods which reflect their experience, crystallized in a form very similar to typical biological laboratory protocols. In order to best aid researchers, the chapters supply the theory behind the method, its step-by-step implementation, and the pitfalls explained thoroughly and from the practical angle. As a volume of the highly successful Methods in Molecular Biology(TM) series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.

Cutting-edge and easy to use, Systems Biology shatters the perceived insurmountable barrier between the laboratory and systems-biological research techniques.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 500
• Erscheinungstermin: 29. April 2009
• Englisch
• ISBN-13: 9781597455251
• Artikelnr.: 64693729

Inhaltsangabe

Introduction: A Practical Guide to the Systems Approach in Biology.- Methods for Analyzing Biomolecular Systems.- Computational Modeling of Biochemical Networks Using COPASI.- Flux Balance Analysis: Interrogating Genome-Scale Metabolic Networks.- Modeling Molecular Regulatory Networks with JigCell and PET.- Rule-Based Modeling of Biochemical Systems with BioNetGen.- Ingeneue: A Software Tool to Simulate and Explore Genetic Regulatory Networks.- Spatial Analysis and Control of Cellular Processes.- Microfluidics Technology for Systems Biology Research.- Systems Approach to Therapeutics Design.- Rapid Creation, Monte Carlo Simulation, and Visualization of Realistic 3D Cell Models.- A Cell Architecture Modeling System Based on Quantitative Ultrastructural Characteristics.- Location Proteomics: Systematic Determination of Protein Subcellular Location.- Methods for Larger-Scale Systems Analysis.- Model-Based Global Analysis of Heterogeneous Experimental Data Using gfit.- Multicell Simulations of Development and Disease Using the CompuCell3D Simulation Environment.- BioLogic: A Mathematical Modeling Framework for Immunologists.- Dynamic Knowledge Representation Using Agent-Based Modeling: Ontology Instantiation and Verification of Conceptual Models.- Systems Biology of Microbial Communities.

Rezensionen

From the reviews: "This volume considers systems biology in the broadest terms: the integration of experimental and mathematical approaches to biological systems with the aim of gaining both predictive and explanatory power. ... the methods are clearly explained and well-illustrated ... . Therefore, this volume will generally be of most value as an institutional purchase." (Conrad Nieduszynski, Microbiology Today, January, 2010)