Bor-Sen Chen

Systems Immunology and Infection Microbiology (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Systems Immunology and Infection Microbiology provides a large amount of biological system models, diagrams and flowcharts to illustrate development procedures and help users understand the results of systems immunology and infection microbiology. Chapters discuss systems immunology, systems infection microbiology, systematic inflammation and immune responses in restoration and regeneration process, systems' innate and adaptive immunity in infection process, systematic genetic and epigenetic pathogenic/defensive mechanism during bacterial infection on human cells is introduced, and the systematic genetic and epigenetic pathogenic/defensive mechanisms during viral infection on human cells.

This book provides new big data-driven and systems-driven systems immunology and infection microbiology to researchers applying systems biology and bioinformatics in their work. It is also invaluable to several members of biomedical field who are interested in learning more about those approaches.

• Encompasses one applicable example in every chapter to illustrate the solution procedure from big data mining, network modeling, host/pathogen cross-talk detection, drug target identification and systems drug design
• Presents flowcharts to represent the development procedure of systematic immunology and infection in a very clear format
• Contains 100 color diagrams to help readers understand the related biological networks, their corresponding mechanisms, and significant network biomarkers for therapeutic drug design

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 672
• Erscheinungstermin: 16. März 2021
• Englisch
• ISBN-13: 9780128173350
• Artikelnr.: 61687781

Autorenporträt

Bor-Sen Chen received B.S. degree of electrical Engineering from Tatung Institute of Technology in 1970, M.S. degree of Geophysics from National Central University in 1973, and PhD in Electrical Engineering from University of Southern California in 1982. He is an expert on the topic of nonlinear robust control and filter designs based on stochastic Nash game theory to override the influence of intrinsic random fluctuations and attenuate the effect of environmental disturbances, which can be applied to evolutionary game strategies of biological networks under natural selection to respond to random genetic variations and environmental disturbances in the evolutionary process. Prof. Chen had audited more than 10 courses of biology before his research in systems biology. He has published about 100 papers in bioinformatics and systems biology. Further, he have published more than 100 papers in system theory and control, and more than 80 papers of signal processing and communication. In the last three years, he has also published 7 monographs. He was elected to an IEEE Fellow in 2001 and became an IEEE Life Fellow in 2014.

Inhaltsangabe

1. Introduction to Systems Immunology and Infection Microbiology
Part I: Systems Immunology2. Biological Network Modeling and System
Identification in Systems Immunology3. Systems Biology Approach to
Construct the Gene Regulatory Network of Systemic Inflammation via
Microarray and Database Mining4. Dynamic Cross-talks Analysis among
Signaling Transduction Pathways in Inflammatory Responses
Part II: Systems Infection Microbiology5. Prediction of
Infection-Associated Genes via a Cellular Network Approach: A C. Albican
Infection Case Study6. Global Screening of Potential C. Albican
Biofilm-Related Transcription Factors (TFs) by Network Comparison via Big
Database Mining and Microarray Data7. Identification of Infection-Related
and Defense-Related Genes through A Dynamic Host-Pathogen Interaction
Network via A C. Albicans-Zebrafish Infection Model8. Host-Pathogen
Interaction Network through Dynamic Interspecies Interaction Model and Big
Database Mining9. Essential Functional Modules for Pathogenic and Defensive
Mechanisms via Host / Pathogen Crosstalk Network Database Mining and
Microarray Data
Part III: Systematic Inflammation and Immune Response in Restoration and
Regeneration Process10. The Role of Inflammation and Immune Response in
Corebella Wound Healing Mechanism After Traumatic Injury in Zebrafish11.
Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke:
Multi-Database Mining and Systems Biology Approach
Part IV: Systems Innate and Adaptive Immunity in the Infection Process12.
Cross-Talk Network Biomarkers of Pathogen-Host Interaction Network from
Innate to Adaptive Immunity13. A Systems Biology Approach to the
Coordination of Defensive and O¿ensive Molecular Mechanisms in the Innate
and Adaptive Host-pathogen Interaction Network14. Role of Signaling
Pathways in Innate and Adaptive Immunity
Part V: Systematic Genetic and Epigenetic pathogenic/ Defensive Mechanism
During Bacterial Infection on Human cells15. Genetic-and-epigenetic
Interspecies Networks for Cross-talk Mechanisms in Human Macrophages and
Dendritic Cells during MTB Infection16. Investigating the Progression of
Cross-talk Mechanism in Caco-2 Cells during Clostridium difficile Infection
by Constructing Genetic and Epigenetic Interspecies Networks: Big Data
Mining and Genome-wide Identification17. Investigating the Common
Pathogenic Mechanism for Drug Design between Different Strains of Candidate
Albicans Infection by Comparing their Genetic and Epigenetic Interspecies
Networks: Big Data Mining and Computational Systems biology Approach
Part VI: Systematic Genetic and Epigenetic pathogen/ Defensive Mechanism
During viral Infection on Human Cells18. Constructing the Genome-wide
Genetic and Epigenetic Interspecies Networks and Investigating Molecular
Mechanisms for Host B Lymphocytes Infected with Epstein-Barr Virus via Big
Data Mining and Genome-wide Identification19. Investigating Host/Pathogen
Cross-talk Network Marker to Reveal Pathogenic and Defensive molecular
Mechanism for Drug Design in HIV Infection Process via Systems Biology
Method and Big Data Mining