Target Discovery and Validation Reviews and Protocols (eBook, PDF)

Emerging Molecular Targets and Treatment Options,Volume 2
Redaktion: Sioud, Mouldy

• Format: PDF

Produktbeschreibung

These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 345
• Erscheinungstermin: 5. Februar 2008
• Englisch
• ISBN-13: 9781597452083
• Artikelnr.: 64701355

Inhaltsangabe

Druggable Signaling Proteins.- DNA Methylation and Histone Modifications in Patients With Cancer.- Wnt Signaling as a Therapeutic Target for Cancer.- The NG2/HMP Proteoglycan as a Cancer Therapeutic Target.- Heterotrimeric G Proteins and Disease.- High-Mobility Group Box-1 Isoforms as Potential Therapeutic Targets in Sepsis.- Antisense Oligonucleotides.- Nucleic Acid-Based Aptamers as Promising Therapeutics in Neoplastic Diseases.- Guidelines for the Selection of Effective Short-Interfering RNA Sequences for Functional Genomics.- Suppression of Apoptosis in the Liver by Systemic and Local Delivery of Small-Interfering RNAs.- Target Validation Using RNA Interference in Solid Tumors.- Validation of Telomerase and Survivin as Anticancer Therapeutic Targets Using Ribozymes and Small-Interfering RNAs.- Collagen-Induced Arthritis in Mice.- Novel Opportunities for Therapeutic Targeting in Systemic Autoimmune Diseases.- Considerations for Target Validation and Industrial Approaches.- Regulatory RNAs.- Treatment Options and Individualized Medicine.

Rezensionen

From the reviews:

"...provide a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical applications." -Anticancer Research

"Review current methods for drug target discovery and validation. ... the chapters are generally well written and clear, and provide extensive references to the current literature. Overall ... provide useful overviews that would provide entry into this field. Novice and more experienced researchers ... would find useful information ... ." (Jonathan B. Chaires, ChemMedChem, Issue 3, 2008)