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This book explains the importance of temperature in toxicological studies, then reviews temperature regulation in homeotherms and poikilotherms, and addresses whole-animal and in vitro studies related to the effects of temperature on toxicity. The text examines thermoregulatory response to toxic insult, and describes hypothermic response in rodents to febrile and hyperthermic reactions in humans. It discusses the relevance of heat and cold stress on human exposures. This volume compares responses of animals, and focuses on endocrine disruption. It considers how toxicants and thermal stress cause the expression of stress proteins, and concludes with an examination of thermoregulatory response to natural toxins and venoms.
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