The Art and Science of Physiologically-Based Pharmacokinetics Modeling (eBook, ePUB)

Redaktion: Cristofoletti, Rodrigo; Rostami-Hodjegan, Amin

• Format: ePub

Produktbeschreibung

This state of the art text describes the science behind the system and drug-dependent components of PBPK models, its applications in translational and regulatory science e.g. guiding drug discovery and development, and supporting precision medicine initiatives.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 344
• Erscheinungstermin: 15. Juli 2024
• Englisch
• ISBN-13: 9781040033173
• Artikelnr.: 70759402

Autorenporträt

Rodrigo Cristofoletti, Ph.D., is Assistant Professor of Pharmacometrics and Systems Pharmacology and Associate Director of Centre for Pharmacometrics and Systems Pharmacology, University of Florida, USA. Amin Rostami-Hodjegan, PhD, FCP, FAAPS, FJSSX, FBPS, is Professor of Systems Pharmacology and Director of Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK and SVP of R&D, Chief Scientific Officer (CSO), Certara, Princeton, USA.

Inhaltsangabe

1. From A Mathematical Model to a Technology, the 100 Years' Evolution of
PBPK
2. Basic principles of PBPK modeling and simulation
3. Oral Drug absorption in special populations: in vivo - in vitro - in
silico evaluation
4. Physiologically based absorption models for complex formulations and
dosage forms
5. Perfusion and permeability-limited distribution models
6. Modeling drug metabolism and excretion
7. Platform Qualification and Model verification
8. Applying PBPK modeling to predict drug-drug interactions
9. Applying PBPK modeling to predict drug exposure in special populations
10. PBPK-based Virtual Bioequivalence Trials to Guide Drug Development
11. Application of PBPK modeling to support clinical pharmacology
regulatory decision-making
12. Physiologically based biopharmaceutics modeling (PBBM) in support of
drug product specifications and biowaiver
13. Integrating PBPK modeling and Organ-on-a-chip systems to inform drug
development