The Biology of Germinal Centers in Lymphoid Tissue (eBook, PDF)

Redaktion: Thorbecke, G. Jeanette; Tsiagbe, Vincent K.

• Format: PDF

Produktbeschreibung

This book meets the demand of a recent surge of interest in germinal centers, the foci of antigen-induced, rapidly proliferating B lymphocytes, representing sites in mammalian lymphoid tissue where memory B cells are generated. Various aspects of the generation of germinal centers, the somatic hypermutation process and the cellular interactions involved in the selection process are discussed in detail. A chapter on germinal center-derived lymphomas completes the treatment.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 241
• Erscheinungstermin: 17. April 2013
• Englisch
• ISBN-13: 9783662131411
• Artikelnr.: 53391804

Inhaltsangabe

1. Overview of Germinal Center Function and Structure in Normal and Genetically Engineered Mice.- 2. The Germinal Center Reaction: Influence of FDC Function in Normal, Aged, and Retrovirus Infected Hosts.- 3. T and B Lymphocytes in Germinal Centers.- 4. Somatic Hypermutation of Immunoglobulin Genes.- 5. Germinal Center Derived Lymphomas in Humans and Mice.- Color Figures.