Min Shi, Feijun Wang, Mei-Xin Zhao, Yin Wei

The Chemistry of the Morita-Baylis-Hillman Reaction (eBook, PDF)

• Format: PDF

Produktbeschreibung

Carbon-carbon bond formations and functional group transformations are the most fundamental reactions for the construction of molecular frameworks and are at the forefront of organic chemistry research. The Morita-Baylis-Hillman (MBH) type reactions possess the two most important requirements - atom economy and generation of multi-functional groups. The last decade has seen exponential growth of the MBH reaction and its applications. In fact, it is already one of the most powerful carbon-carbon bond-forming methods widely used in organic synthesis. Since the 1990s, more and more research groups have initiated work on different aspects of the MBH reaction. These have focused on the scope of the substrates, novel catalysts (especially chiral catalysts), reaction mechanisms, and synthetic applications. Consequently, there is now a need for a reference detailing the chemistry of this important reaction. This unique book summarizes the MBH reaction, aza-MBH reaction and asymmetric MBH/aza-MBH reaction including the latest research and mechanistic investigations. It provides a complete overview of MBH-type reactions aimed at synthetic organic chemists of all levels within academia and industry. The chapters cover the; origin and growth of the Morita-Baylis-Hillman reaction; reactant classes and reaction conditions; catalytic mechanisms; achiral and chiral catalytic systems; transformations of functional groups; use of Morita-Baylis-Hillman adducts and derivatives as starting materials to construct compounds with carbocyclic or heterocyclic frameworks, and the applications of the MBH reaction in synthesizing natural products.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 705
• Erscheinungstermin: 4. April 2011
• Englisch
• ISBN-13: 9781849732659
• Artikelnr.: 44762633

Autorenporträt

I am currently a professor of organic chemistry in the State Key Lab. of Organometallic Chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, where I have been for ten years. My research focuses on the organic synthesis, asymmetric catalysis, organocatalysis, and chemical fixation of CO2. With my twenty years research experiences in these fields, I have a broad body of knowledge in organic chemistry and organometallics and I am familiar with the frontier work in these areas. My research work was published on the most prestigious journals in the world, such as Angew. Chem. Int. Ed., J. Am. Chem. Soc., Chem. Eur. J., Adv. Synth. & Catal., etc. Thus far, I have published 312 regular papers in above journals. I am also a regularly invited reviewer to evaluate submitted scientific papers for multiple journals. In my research career, I have accomplished several significant jobs on aza-Morita-Baylis-Hillman reaction. Please see the following references.

Inhaltsangabe

Morita
Baylis
Hillman Reaction; Catalytic System for the Morita
Baylis
Hillman Reaction; Transformations of Functional Groups in Morita
Baylis
Hillman Adducts; Morita
Baylis
Hillman Adducts or Derivatives for the Construction of Cyclic Frameworks; The application of Morita
Baylis
Hillman Reaction for the Synthesis of Natural Products