The Chemokine Receptors (eBook, PDF)

Redaktion: Harrison, Jeffrey K.; Lukacs, Nicholas W.

• Format: PDF

Produktbeschreibung

To date, there are over twenty different chemokine receptors, binding nearly fifty unique ligands that have been identified. In Chemokine Receptors, leading investigators attempt to distill the large body of literature ranging from basic molecular and cellular mechanism of chemokine receptors, to physiological and pathological roles of chemokines. Chemokines exhibit a tremendous functional diversity and participate in a wide variety of processes that include inflammation, innate and adaptive immunity, immune cell differentiation, angiogenesis, tumorigenesis, development, neurobiology and viral pathogenesis. Chemokine Receptors targets the pharmaceutical industry, provides an authoritative perspective on the future direction of this field, and insights into areas of active development of novel therapeutics.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 403
• Erscheinungstermin: 17. November 2007
• Englisch
• ISBN-13: 9781597450201
• Artikelnr.: 37347515

Inhaltsangabe

The Birth and Maturation of Chemokines and Their Receptors.- The Structural Biology of Chemokines.- Chemokine Receptors: A Structural Overview.- Chemokine Signaling in T-Lymphocyte Migration: The Role of Phosphoinositide 3-kinase.- Chemokine Receptors and Neutrophil Trafficking.- Chemokine Receptors and Dendritic Cell Trafficking.- Chemokine Receptors and Lymphocyte Trafficking.- Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis.- Chemokines in Transplantation Biology.- The Chemokine System and Arthritis.- Chemokine Receptors in Atherosclerosis.- Chemokine Receptors in Allergic Lung Disease.- Chemokine Receptors and HIV/AIDS.- Chemokines and Their Receptors in Fibrosis.- Chemokines and Angiogenesis.- Chemokine Receptors in Cancer: Pathobiology and Potential Therapeutic Targets.- Chemokine Receptors in Neuroinflammation.- Pharmaceutical Targeting of Chemokine Receptors.

Rezensionen

From the reviews:

"This book aims to report the knowledge concerning chemokines and their receptors in the context of human physiology, pathology, and future therapeutic possibilities. ... this book gives an interesting analysis of the different fields of knowledge and research concerning chemokines and their receptors in recent years. In this way, this book remains interesting for less experienced and mature researchers ... ." (Liliane Gattegno, ChemMedChem, Issue 3, 2008)

"The Chemokine Receptors is an impressive and timely overview of the current knowledge in this field. The target readership includes researchers ... clinicians including infectiologists, rheumatologists, oncologists and others may surely find information in this book, shedding light on their field of medicine. As such, the book can be used both by people entering the field and by more experienced researchers seeking new insights. ... The volume contains numerous figures (including colour plates) as well as informative tables."(F. De Keyser, Acta Clinica Belgica, Vol. 63 (4), 2008)