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As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written…mehr
As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.
Historical Overview: Introduction to the Dopamine Receptors.- Gene and Promoter Structures of the Dopamine Receptors.- Structural Basis of Dopamine Receptor Activation.- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors.- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors.- Dopamine Receptor Signaling: Intracellular Pathways to Behavior.- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons.- Regulation of Dopamine Receptor Trafficking and Responsiveness.- Dopamine Receptor-Interacting Proteins.- Dopamine Receptor Oligomerization.- Dopamine Receptor Modulation of Glutamatergic Neurotransmission.- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice.- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models.- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function.- In Vivo Imaging of Dopamine Receptors.- Dopamine Receptors and the Treatment of Schizophrenia.- Dopamine Receptor Subtypes in Reward and Relapse.- Dopamine Receptors and the Treatment of Parkinson’s Disease.- Dopamine Receptor Genetics in Neuropsychiatric Disorders.
Historical Overview: Introduction to the Dopamine Receptors.- Gene and Promoter Structures of the Dopamine Receptors.- Structural Basis of Dopamine Receptor Activation.- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors.- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors.- Dopamine Receptor Signaling: Intracellular Pathways to Behavior.- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons.- Regulation of Dopamine Receptor Trafficking and Responsiveness.- Dopamine Receptor-Interacting Proteins.- Dopamine Receptor Oligomerization.- Dopamine Receptor Modulation of Glutamatergic Neurotransmission.- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice.- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models.- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function.- In Vivo Imaging of Dopamine Receptors.- Dopamine Receptors and the Treatment of Schizophrenia.- Dopamine Receptor Subtypes in Reward and Relapse.- Dopamine Receptors and the Treatment of Parkinson's Disease.- Dopamine Receptor Genetics in Neuropsychiatric Disorders.
Historical Overview: Introduction to the Dopamine Receptors.- Gene and Promoter Structures of the Dopamine Receptors.- Structural Basis of Dopamine Receptor Activation.- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors.- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors.- Dopamine Receptor Signaling: Intracellular Pathways to Behavior.- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons.- Regulation of Dopamine Receptor Trafficking and Responsiveness.- Dopamine Receptor-Interacting Proteins.- Dopamine Receptor Oligomerization.- Dopamine Receptor Modulation of Glutamatergic Neurotransmission.- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice.- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models.- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function.- In Vivo Imaging of Dopamine Receptors.- Dopamine Receptors and the Treatment of Schizophrenia.- Dopamine Receptor Subtypes in Reward and Relapse.- Dopamine Receptors and the Treatment of Parkinson’s Disease.- Dopamine Receptor Genetics in Neuropsychiatric Disorders.
Historical Overview: Introduction to the Dopamine Receptors.- Gene and Promoter Structures of the Dopamine Receptors.- Structural Basis of Dopamine Receptor Activation.- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors.- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors.- Dopamine Receptor Signaling: Intracellular Pathways to Behavior.- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons.- Regulation of Dopamine Receptor Trafficking and Responsiveness.- Dopamine Receptor-Interacting Proteins.- Dopamine Receptor Oligomerization.- Dopamine Receptor Modulation of Glutamatergic Neurotransmission.- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice.- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models.- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function.- In Vivo Imaging of Dopamine Receptors.- Dopamine Receptors and the Treatment of Schizophrenia.- Dopamine Receptor Subtypes in Reward and Relapse.- Dopamine Receptors and the Treatment of Parkinson's Disease.- Dopamine Receptor Genetics in Neuropsychiatric Disorders.
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...extremely well-written and thoroughly referenced... All neuroscientists searching for an invaluable reference which provides a clearer understanding of the dopamine field and its future direction should have this book at their fingertips. -Journal of Medicinal Chemistry
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