Tore Samuelsson

The Human Genome in Health and Disease (eBook, ePUB)

A Story of Four Letters

• Format: ePub

Produktbeschreibung

The Human Genome in Health and Disease explores the intimate link between sequence information and biological function. A range of sequence-based functional units of the genome are discussed and illustrated with inherited disorders and cancer.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 297
• Erscheinungstermin: 7. Februar 2019
• Englisch
• ISBN-13: 9780429664298
• Artikelnr.: 56887469

Autorenporträt

Tore Samuelsson

Inhaltsangabe

1. Introduction

2. A Molecular Disorder

3. A Code of Life

4. The Genome

5. Variants in the Human Genome Sequence and Their Biological Significance

6. The Critical Protein Coding Sequences

7. Triplet Repeats and Neurodegenerative Disorders

8. The Untranslated Parts of a Message

9. Exons, Introns, and a Royal Bleeding Disorder

10. The Regulation of Transcription

11. The Noncoding RNAs

12. Computational Methods Are Critical in the Analysis of Molecular Sequences

13. Diagnosing the Genome

14. Correcting Genome Errors

15. Epilogue

Appendixes

Glossary

Recommended Textbooks for Further Reading

Index

Rezensionen

"... an excellent primer on the molecular and biochemical underpinnings of disease. The author walks us through how the genome is structured and regulated, interspaced with detailed explanations of how changes in the genome result in biological function and human disease. He includes personal touches that help humanize the material, ..." - The Quarterly Review of Biology, 95(2).

"Although the material is appropriate for advanced biology students, this volume would also be suitable for those with limited knowledge of biology due to the detailed and careful walkthrough of the topic matter that makes it approachable for nonspecialists, especially for fledgling computational biologists or clinical geneticists, and even for nonacademics who wish to better understand their own genome." - William Gillis, Biological Sciences, State University of New York College at Old Westbury