The Immunological Synapse - Part B (eBook, ePUB)

• Format: ePub

Produktbeschreibung

The Immunological Synapse - Part B, Volume 178 in the Methods in Cell Biology series provides state-of-the-art methods for the study of the immunological synapse. This first volume covers various aspects on T cell and natural killer (NK) cell synapses, including imaging polarized granule release using TIRF microscopy, analysis of actin reorganization and centrosome polarization, redirected degranulation, live cell-imaging to quantify cytotoxic and chemotactic dynamics, quantification of interactions between APCs and T cells, assessment of membrane lipid state at the immunological synapse, proteomic analysis and imaging of NK-tumor cell interaction, evaluating natural killer cell effector functions against breast cancer cells derived from human tumor tissue, evaluation of chimeric antigen receptor (CAR)-modified cell immunological synapse quality using the glass-supported planar lipid bilayer, and monitoring potency of therapeutic CAR T cells. It also includes one chapter on quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, and one chapter on the murine antibody-dependent cellular phagocytosis assay.

• Covers various methods related to the study of the immunological synapse
• Includes detailed, point-by-point, methods as well as various important notes
• Provides the authority and expertise from an international board of leading scientists

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 318
• Erscheinungstermin: 27. Juli 2023
• Englisch
• ISBN-13: 9780443191640
• Artikelnr.: 68497015