Biology and Pathobiology Redaktion: Arias, Irwin M.; Wolkoff, Allan W.; Thorgeirsson, Snorri S.; Shafritz, David A.; Cohen, David E.; Boyer, James L.; Alter, Harvey J.
Biology and Pathobiology Redaktion: Arias, Irwin M.; Wolkoff, Allan W.; Thorgeirsson, Snorri S.; Shafritz, David A.; Cohen, David E.; Boyer, James L.; Alter, Harvey J.
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Bridging the gap between basic scientific advances and the understanding of liver disease -- the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver's growth, regeneration, metabolic functions, and more. Now…mehr
Bridging the gap between basic scientific advances and the understanding of liver disease -- the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver's growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters -- including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology -- provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: * Relates molecular physiology to understanding disease pathology and treatment * Links the science and pathology of the liver to practical clinical applications * Features 16 new "Horizons" chapters that explore new and emerging science and technology * Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
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IRWIN M. ARIAS, MD, National Institutes of Health, Bethesda, Maryland, USA. HARVEY J. ALTER, MD, National Institutes of Health, Bethesda, Maryland, USA. JAMES L. BOYER, MD, Yale University School of Medicine, New Haven, Connecticut, USA. DAVID E. COHEN, MD, Weill Cornell Medical College, New York, USA. DAVID A. SHAFRITZ, MD, Albert Einstein College of Medicine, New York, USA. SNORRI S. THORGEIRSSON, MD, National Institutes of Health, Bethesda, Maryland, USA. ALLAN W. WOLKOFF, MD, Albert Einstein College of Medicine, New York, USA.
Inhaltsangabe
List of Contributors x
Preface xx
Acknowledgments xxi
Part One: Introduction 1
1 Organizational Principles of the Liver 3 Peter Nagy, Snorri S. Thorgeirsson, and Joe W. Grisham
2 Embryonic Development of the Liver 14 Kenneth S. Zaret, Roque Bort, and Stephen A. Duncan
Part Two: The Cells 23
Section A: Cell Biology of the Liver 25
3 Cytoskeletal Motors: Structure and Function in Hepatocytes 27 Mukesh Kumar, Arnab Gupta, and Roop Mallik
4 Hepatocyte Surface Polarity 36 Anne Müsch and Irwin M. Arias
5 Primary Cilia 50 Carolyn M. Ott
6 Endocytosis in Liver Function and Pathology 62 Micah B. Schott, Barbara Schroeder, and Mark A. McNiven
7 The Hepatocellular Secretory Pathway 75 Catherine L. Jackson and Mark A. McNiven
8 Mitochondrial Function, Dynamics, and Quality Control 86 Marc Liesa, Ilan Benador, Nathanael Miller, and Orian S. Shirihai
9 Nuclear Pore Complex 94 Michelle A. Veronin and Joseph S. Glavy
10 Protein Maturation and Processing at the Endoplasmic Reticulum 108 Ramanujan S. Hegde
11 Protein Degradation and the Lysosomal System 122 Susmita Kaushik and Ana Maria Cuervo
12 Peroxisome Assembly, Degradation, and Disease 137 Rong Hua and Peter K. Kim
13 Organelle-Organelle Contacts: Origins and Functions 151 Uri Manor
14 Gap and Tight Junctions in Liver: Structure, Function, and Pathology 160 John W. Murray and David C. Spray
15 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver 174 Katherine I. Farley-Barnes and Susan J. Baserga
16 miRNAs and Hepatocellular Carcinoma 183 Yusuke Yamamoto, Isaku Kohama, and Takahiro Ochiya
17 Hepatocyte Apoptosis: Mechanisms and Relevance in Liver Diseases 195 Harmeet Malhi and Gregory J. Gores
Section B: The Hepatocyte 207
18 Copper Metabolism and the Liver 209 Cynthia Abou Zeid, Ling Yi, and Stephen G. Kaler
19 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis 215 Tracey A. Rouault, Victor R. Gordeuk, and Gregory J. Anderson
20 Disorders of Bilirubin Metabolism 229 Namita Roy Chowdhury, Yanfeng Li, and Jayanta Roy Chowdhury
21 Hepatic Lipid Droplets in Liver Function and Disease 245 Douglas G. Mashek, Wenqi Cui, Linshan Shang, and Charles P. Najt
22 Lipoprotein Metabolism and Cholesterol Balance 255 Mariana Acuña-Aravena and David E. Cohen
Section C: Transporters, Bile Acids, and Cholestasis 269
23 Bile Acid Metabolism in Health and Disease: An Update 271 Tiangang Li and John Y.L. Chiang
24 TGR5 (GPBAR1) in the Liver 286 Verena Keitel, Christoph G.W. Gertzen, Lina Spomer, Holger Gohlke, and Dieter Häussinger
25 Bile Acids as Signaling Molecules 299 Thierry Claudel and Michael Trauner
26 Hepatic Adenosine Triphosphate-Binding Cassette Transport Proteins and Their Role in Physiology 313 Peter L.M. Jansen
27 Basolateral Plasma Membrane Organic Anion Transporters 327 M. Sawkat Anwer and Allan W. Wolkoff
28 Hepatic Nuclear Receptors 337 Raymond E. Soccio
29 Molecular Cholestasis 351 Paul Gissen and Richard J. Thompson
30 Pathophysiologic Basis for Alternative Therapies for Cholestasis 364 Claudia D. Fuchs, Emina Halilbasic, and Michael Trauner
31 Adaptive Regulation of Hepatocyte Transporters in Cholestasis 378 James L. Boyer
Section D: Non-Hepatocyte Cells 391
32 Cholangiocyte Biology and Pathobiology 393 Massimiliano Cadamuro, Romina Fiorotto, and Mario Strazzabosco
1 Organizational Principles of the Liver 3 Peter Nagy, Snorri S. Thorgeirsson, and Joe W. Grisham
2 Embryonic Development of the Liver 14 Kenneth S. Zaret, Roque Bort, and Stephen A. Duncan
Part Two: The Cells 23
Section A: Cell Biology of the Liver 25
3 Cytoskeletal Motors: Structure and Function in Hepatocytes 27 Mukesh Kumar, Arnab Gupta, and Roop Mallik
4 Hepatocyte Surface Polarity 36 Anne Müsch and Irwin M. Arias
5 Primary Cilia 50 Carolyn M. Ott
6 Endocytosis in Liver Function and Pathology 62 Micah B. Schott, Barbara Schroeder, and Mark A. McNiven
7 The Hepatocellular Secretory Pathway 75 Catherine L. Jackson and Mark A. McNiven
8 Mitochondrial Function, Dynamics, and Quality Control 86 Marc Liesa, Ilan Benador, Nathanael Miller, and Orian S. Shirihai
9 Nuclear Pore Complex 94 Michelle A. Veronin and Joseph S. Glavy
10 Protein Maturation and Processing at the Endoplasmic Reticulum 108 Ramanujan S. Hegde
11 Protein Degradation and the Lysosomal System 122 Susmita Kaushik and Ana Maria Cuervo
12 Peroxisome Assembly, Degradation, and Disease 137 Rong Hua and Peter K. Kim
13 Organelle-Organelle Contacts: Origins and Functions 151 Uri Manor
14 Gap and Tight Junctions in Liver: Structure, Function, and Pathology 160 John W. Murray and David C. Spray
15 Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver 174 Katherine I. Farley-Barnes and Susan J. Baserga
16 miRNAs and Hepatocellular Carcinoma 183 Yusuke Yamamoto, Isaku Kohama, and Takahiro Ochiya
17 Hepatocyte Apoptosis: Mechanisms and Relevance in Liver Diseases 195 Harmeet Malhi and Gregory J. Gores
Section B: The Hepatocyte 207
18 Copper Metabolism and the Liver 209 Cynthia Abou Zeid, Ling Yi, and Stephen G. Kaler
19 The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis 215 Tracey A. Rouault, Victor R. Gordeuk, and Gregory J. Anderson
20 Disorders of Bilirubin Metabolism 229 Namita Roy Chowdhury, Yanfeng Li, and Jayanta Roy Chowdhury
21 Hepatic Lipid Droplets in Liver Function and Disease 245 Douglas G. Mashek, Wenqi Cui, Linshan Shang, and Charles P. Najt
22 Lipoprotein Metabolism and Cholesterol Balance 255 Mariana Acuña-Aravena and David E. Cohen
Section C: Transporters, Bile Acids, and Cholestasis 269
23 Bile Acid Metabolism in Health and Disease: An Update 271 Tiangang Li and John Y.L. Chiang
24 TGR5 (GPBAR1) in the Liver 286 Verena Keitel, Christoph G.W. Gertzen, Lina Spomer, Holger Gohlke, and Dieter Häussinger
25 Bile Acids as Signaling Molecules 299 Thierry Claudel and Michael Trauner
26 Hepatic Adenosine Triphosphate-Binding Cassette Transport Proteins and Their Role in Physiology 313 Peter L.M. Jansen
27 Basolateral Plasma Membrane Organic Anion Transporters 327 M. Sawkat Anwer and Allan W. Wolkoff
28 Hepatic Nuclear Receptors 337 Raymond E. Soccio
29 Molecular Cholestasis 351 Paul Gissen and Richard J. Thompson
30 Pathophysiologic Basis for Alternative Therapies for Cholestasis 364 Claudia D. Fuchs, Emina Halilbasic, and Michael Trauner
31 Adaptive Regulation of Hepatocyte Transporters in Cholestasis 378 James L. Boyer
Section D: Non-Hepatocyte Cells 391
32 Cholangiocyte Biology and Pathobiology 393 Massimiliano Cadamuro, Romina Fiorotto, and Mario Strazzabosco
33 Polycystic Liver Diseases: Genetics, Mec
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