The Medicinal Chemist's Guide to Solving ADMET Challenges (eBook, ePUB)

Redaktion: Schnider, Patrick

• Format: ePub

Produktbeschreibung

The Medicinal Chemist's Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual "table-of-contents" style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist's Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 518
• Erscheinungstermin: 20. August 2021
• Englisch
• ISBN-13: 9781839160493
• Artikelnr.: 62483995

Inhaltsangabe

Solubility
Efflux transporters
Cytochrome P450 metabolism
Cytochrome P450 induction
Cytochrome P450 inhibition
Aldehyde & xanthine oxidase metabolism
Reactive metabolites
Phototoxicity
Glucuronidation & sulfation
Phospholipidosis
hERG potassium channel inhibition
Genotoxicity
Sodium & calcium channel inhibition
Passive Permeability
Uptake Transporters in the GI
Organic anion and cation transporters from the SLC22 and SLCO families
Bile salt export pump inhibition