The Melanocortin Receptors (eBook, PDF)

Redaktion: Cone, Roger D.

• Format: PDF

Produktbeschreibung

In The Melanocortin Receptors, Roger Cone and a distinguished team of expert investigators provide the first major treatment of this critically important receptor family. The book illuminates the structure and function of these receptors through a wide-ranging review of the latest findings concerning the biology, physiology, and pharmacology of their peptide ligands and covers the major melanocortin receptors, MC1-R through MC5-R. Topics include the characterization of the melanocortin receptors, the biochemical mechanism of receptor action, and receptor function and regulation. Several articles provide historical perspectives on important aspects of melanocortin biology and on the direction of future experimental and clinical research. Timely and authoritative, The Melanocortin Receptors offers an up-to-date knowledge base on the remarkably complex of structure and functions of the melanocortins, a guide that will prove invaluable for today's neuroscientists, endocrinologists, pharmacologists, dermatologists, and other clinical and experimental investigators working in this fast moving field.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 542
• Erscheinungstermin: 14. März 2000
• Englisch
• ISBN-13: 9781592590315
• Artikelnr.: 43994615

Inhaltsangabe

I. Historical Perspectives.- 1 - Proopiomelanocortin and the Melanocortin Peptides.- 2 - Melanocortins and Pigmentation.- 3 - Melanocortins and Adrenocortical Function.- 4 - Effects of Melanocortins in the Nervous System.- 5 - Peripheral Effects of Melanocortins.- II. Characterization of the Melanocortin Receptors.- 6 - Melanocortin Receptor Expression and Function in the Nervous System.- 7 - Cloning of the Melanocortin Receptors.- III. Biochemical Mechanism of Receptor Action.- 8 - The Molecular Pharmacology of Alpha-Melanocyte Stimulating Hormone: Structure Activity Relationships for Melanotropins at Melanocortin Receptors.- 9 - In Vitro Mutagenesis Studies of Melanocortin Receptor Coupling and Ligand Binding.- IV. Receptor Function.- 10 - The Melanocortin-1 Receptor.- 11 - The Human Melanocortin-1 Receptor.- 12 - The Melanocortin-2 Receptor in Normal Adrenocortical Function and Familial Adrenocorticotropic Hormone Resistance.- 13 - The Melanocortin-3 Receptor.- 14 - The Melanocortin-4 Receptor.- 15 - The Melanocortin-5 Receptor.- V. Receptor Regulation.- 16 - Regulation of the Melanocortin Receptors by Agouti.- 17 - Melanocortins and Melanoma.- 18 - Regulation of the Mouse and Human Melanocortin-1 Receptor.- VI. Future Vistas.- 19 - Future Vistas.

Rezensionen

"New data on melanocortin receptors 1-5 and their regulation are the topic of several chapters. A complete, well referenced text of interest to all endocrinologists, neuroscientists, geneticists, physiologists and pharmacologists." - Journal of Pediatric Endocrinology & Metabolism