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From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's…mehr
From basic science to clinical care, to epidemiological disease patters, The Neurology of AIDS is the only complete textbook available on AIDS neurology and the only one comprehensive enough to stand alone in each segment of study in brain disorders affected by the human immunodeficiency virus. It is an indispensable resource for students, resident physicians, practicing physicians, and for researchers and experts in the HIV/AIDS field. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
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Autorenporträt
Howard E. Gendelman, MD, Professor and Chair, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center Omaha, NE. Igor Grant, MD, Distinguished Professor of Psychiatry, Director, HIV Neurobehavioral Research Program, University of California-San Diego, La Jolla, CA. Ian Paul Everall, MD, PhD, Professor of Psychiatry and Head of Department, University of Melbourne, Victoria, Australia. Howard S. Fox, MD, PhD, Professor, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE. Harris A. Gelbard, MD, PhD, Director of The Center for Neural Development and Disease, Professor of Neurology, Pediatrics, Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY. Stuart A. Lipton, MD, PhD, Professor and Scientific Director, Sanford-Burnham Medical Research Institute; Adjunct Professor of Neurosciences, University of California-San Diego; Adjunct Professor, The Salk Institute for Biological Studies and The Scripps Research Institute, La Jolla, CA. Susan Swindells, MBBS, Professor of Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.
Inhaltsangabe
* Section 1. HIV-1 Biology and Immunology * 1.1. HIV-1 Biology Michael Bukrinsky and Sergey Iordanskiy * 1.2. HIV-1 Immunology Sabita Roy Subhash Dhawan Shilpa Buch and Krishnakumar Devadas * 1.3 Chemokines Richard J. Miller * 1.4 Viral and host genetic factors Christopher Power Jennifer A. McCombe Shaona Acharjee and M. John Gill * 1.5 Genetic Susceptibilities in neuroAIDS Sunil K. Ahuja Srinivas Mummidi Jason F. Okulicz Edwina J. Wright and Weijing He * Section 2. Innate and Cellular Immunity and Neurogenesis * 2.1. Mononuclear phagocytes Kenneth C. Williams William Hickey Tricia H. Burdo and Caroline Soulas * 2.2. Microglia Sunhee C. Lee * 2.3. Astrocytes Etty N. Benveniste Lisa N. Akhtar and Brandi J. Baker * 2.4. Adaptive Immunity Howard E. Gendelman Jessica A.L. Hutter Larisa Poluektova and Subhash Dhawan * 2.5. Vaccines R. Lee Mosley Max V. Kuenstling and Eric J. Benner * 2.6. Neurogenesis Jialin C. Zheng James B Reinecke Hui Peng Yunlong Huang and Qiang Chen * Section 3. Blood brain barrier and HIV CNS Entry * 3.1. Blood brain barrier: Structure and function William A. Banks * 3.2. Endothelial cell biology and HIV-1 infection Michal Toborek Ibolya E. András Cetewayo S. Rashid Yu Zhong and Shinsuke Nakagawa * 3.3. Blood-brain barrier during neuroinflammation Yuri Persidsky and Servio H. Ramirez * 3.4. Mechanisms of viral and cell entry into the CNS Eliseo A. Eugenin and J.W. Berman * 3.5. Monocyte-macrophages and viral CNS entry Georgette D. Kanmogne * Section 4. Cellular and Viral Neurotoxicity and Abused Drugs * 4.1. Mononuclear phagocyte inflammation and neurotoxicity Howard E. Gendelman Andrea Martinez-Skinner Ari Nowacek and JoEllyn McMillan * 4.2. Neurotoxicity of HIV-1 proteins Ruth Brack-Werner Manja Meggendorfer Ina Rothenaigner Bianca Tigges and Michelle Vincendea * 4.3. HIV-1 and Tat Avindra Nath Wenxue Li Guanhan Li and Joseph Steiner * 4.4. HIV-1 gp120 Stuart A. Lipton Shu-ichi Okamoto Marcus Kaul Ian Paul Everall and Eliezer Masliah * 4.5. HIV-1 and cannabinoids Guy A. Cabral and Erinn S. Raborn * 4.6. HIV-1 and METH Howard S. Fox * 4.7. HIV-1 and Opioids Toby K. Eisenstein Jessica Breslow Changcheng Song Mathew J. Finley William D. Cornwell Sumedha Chugh Joseph J. Meissler and Thomas J. Rogers * 4.8. HIV-1 and Cocaine Shilpa J. Buch Honghong Yao and Sabita Roy * Section 5. Animal models * 5.1. SIV Janice E. Clements M. Christine Zink Joseph L. Mankowski David R. Graham and Lucio Gama * 5.2. FIV Rick B. Meeker * 5.3. CAEV Valgerdur Andrésdóttir Sigurbjörg Torsteinsdóttir and Gudmundur Georgsson * 5.4. Transgenics Sulie L. Chang and Marley D. Kass * 5.5. Immunodeficient mice Larisa Poluektova * 5.6. SIV and opiates Shilpa J. Buch Shannon Callen Paul Cheney and Anil Kumar * 5.7. SIV and FIV and peripheral neuropathy Joseph L. Mankowski Victoria A. Laast Gigi Ebenezer and Justin C. McArthur * 5.8. Animal models and bioimaging R. Gilberto González Eva-Maria Ratai and Margaret R. Lentz * Section 6. Personal Perspectives in Living with HIV/AIDS * 6.1. Darren Kane * 6.2. Eric Glare * 6.3. James May * 6.4. Karen * 6.5. Susan Paxton * Section 7. Clinical and Pathologic Manifestations of Disease * 7.1. Prospective on HIV CNS Infections Richard W. Price * 7.2. HAND Igor Grant and Ned Sacktor * 7.3. Early Manifestations of CNS Disease Serena S. Spudich * 7.4. HIV-1 Neuropathology Benjamin B. Gelman and David J. Moore * 7.5. Peripheral Neuropathy David M. Simpson Kathryn J. Elliott and Justin McArthur * 7.6. Spinal Cord Disease Christina M. Marra * 7.7. Myopathy Susan Morgello Jessica Robinson-Papp Kenneth A. Fox and David M. Simpson * 7.8. Aging Christian L. Achim and Virawudh Soontornniyomkij * 7.9. Addiction R. Douglas Bruce * Chapter 8. Pathogenesis of Co-Morbid Conditions * 8.1. NeuroAIDS as an Inflammatory Disorder Dennis L. Kolson Denise R. Cooka Stephanie A. Crossa and Samantha S. Soldana * 8.2. Neuronal Injury White Matter Disease and Neurotrophic Factors Dianne Langford Eliezer Masliah and Ian Paul Everall * 8.3. Pathobiology of HIV-related neuropathies BJ Brew and NWS Davies * 8.4. CNS Co-morbidities Georgette D. Kanmogne and David B. Clifford * 8.5. Opportunistic Infections Joseph R. Berger and Bruce A. Cohen * 8.6. PML Eugene O. Major and Maria Chiara G. Monaco * 8.7. Neoplasms Alexis Demopoulos and Lauren Abrey * 8.8. Hepatitis C Wenzhe Ho and Li Ye * 8.9. Psychiatric Co-Morbidities Ian Paul Everall and Timothy B. Nguyen * Chapter 9. Diagnostics and Biomarkers * 9.1. Brain Imaging Linda Chang Ute Feger and Thomas Ernst Ph.D. * 9.2. MRI Terry L. Jernigan Sarah L. Archibald and Christine Fennema-Notestine * 9.3. Psychological Evaluations Steven Paul Woods Jordan Elizabeth Cattie and Igor Grant * 9.4. Viral and Cellular Biomarkers During Antiretroviral Therapy Scott L. Letendre * 9.5. Viral Dynamics Ronald J. Ellis and Davey M. Smith * 9.6. Viral Clades Avindra Nath and Wenxue Li * 9.7. Proteomics and Biomarkers Pawel Ciborowski Gwenael Pottiez and Jayme Wiederin * Chapter 10. Children and Adolescents * 10.1. Clinical and Pathological Features of HIV-1 Encephalopathy in Children and Adolescents Mark Mintz Leroy Sharer and Lucy Civitello * 10.2. Infants Children and Adolescents Nervous System Disease in the era of combination antiretroviral therapy Annelies Van Rie and Anna Dow * 10.3. Psychosocial Aspects of Neurologic Impairment in Children with AIDS Lori Wiener and Claude Mellins * 10.4. Growing up with HIV Disease Lynnae Schwartz Leslie K. Serchuck and Shirley F. Delair * Chapter 11. Antiretroviral and Adjunctive Therapies * 11.1. Current Concepts in the Treatment of HIV Infection with Focus on Brain Disease Susan Swindells and Uriel Sandkovsky * 11.2. Pharmacology of Antiretroviral Therapies J. Allen McCutchan Scott Letendre Ronald J. Ellis Brookie Best and Edmund Capparelli * 11.3. Treatment of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection David B. Clifford * 11.4. Nanoformulated Medicines Howard E. Gendelman Upal Roy Shantanu Balkundi and JoEllyn McMillan * 11.5. Antiretroviral nanotherapies Madhavan P.N. Nair and Zainulabedin M. Saiyed * 11.6. Adjunctive Medicines Harris A. Gelbard and Stuart A. Lipton * Chapter 12. Psychiatry and Psychobiology * 12.1. Psychiatric Disorders J. Hampton Atkinson Nichole A. Duarte and Glenn Treisman * 12.2. Neuropsychiatry of Substance Abuse Eileen M. Martin-Thomas Andy Levine and Raul Gonzalez * 12.3. Psychobiology of Risk Behavior David G. Ostrow * 12.4. Everyday Impact of HIV-Associated Neurocognitive Disorders Thomas D. Marcotte J. Cobb Scott Charles H. Hinkin and Robert K. Heaton * 12.5. Facing Legal and Ethical Challenges in the Treatment of AIDS Glenn J. Treisman and Warren B. Treisman * 12.6. Neuropsychological Testing Kevin R. Robertson Kevin J. Liner Michelle Ro and Robert K. Heaton * 12.7. The impact of HIV subtype cultural and sociodemographic factors on HIV-1 infection and associated neuropathogenesis in Africa Adelina Holguin Damien C. Tully and Charles Wood
* Section 1. HIV-1 Biology and Immunology * 1.1. HIV-1 Biology Michael Bukrinsky and Sergey Iordanskiy * 1.2. HIV-1 Immunology Sabita Roy Subhash Dhawan Shilpa Buch and Krishnakumar Devadas * 1.3 Chemokines Richard J. Miller * 1.4 Viral and host genetic factors Christopher Power Jennifer A. McCombe Shaona Acharjee and M. John Gill * 1.5 Genetic Susceptibilities in neuroAIDS Sunil K. Ahuja Srinivas Mummidi Jason F. Okulicz Edwina J. Wright and Weijing He * Section 2. Innate and Cellular Immunity and Neurogenesis * 2.1. Mononuclear phagocytes Kenneth C. Williams William Hickey Tricia H. Burdo and Caroline Soulas * 2.2. Microglia Sunhee C. Lee * 2.3. Astrocytes Etty N. Benveniste Lisa N. Akhtar and Brandi J. Baker * 2.4. Adaptive Immunity Howard E. Gendelman Jessica A.L. Hutter Larisa Poluektova and Subhash Dhawan * 2.5. Vaccines R. Lee Mosley Max V. Kuenstling and Eric J. Benner * 2.6. Neurogenesis Jialin C. Zheng James B Reinecke Hui Peng Yunlong Huang and Qiang Chen * Section 3. Blood brain barrier and HIV CNS Entry * 3.1. Blood brain barrier: Structure and function William A. Banks * 3.2. Endothelial cell biology and HIV-1 infection Michal Toborek Ibolya E. András Cetewayo S. Rashid Yu Zhong and Shinsuke Nakagawa * 3.3. Blood-brain barrier during neuroinflammation Yuri Persidsky and Servio H. Ramirez * 3.4. Mechanisms of viral and cell entry into the CNS Eliseo A. Eugenin and J.W. Berman * 3.5. Monocyte-macrophages and viral CNS entry Georgette D. Kanmogne * Section 4. Cellular and Viral Neurotoxicity and Abused Drugs * 4.1. Mononuclear phagocyte inflammation and neurotoxicity Howard E. Gendelman Andrea Martinez-Skinner Ari Nowacek and JoEllyn McMillan * 4.2. Neurotoxicity of HIV-1 proteins Ruth Brack-Werner Manja Meggendorfer Ina Rothenaigner Bianca Tigges and Michelle Vincendea * 4.3. HIV-1 and Tat Avindra Nath Wenxue Li Guanhan Li and Joseph Steiner * 4.4. HIV-1 gp120 Stuart A. Lipton Shu-ichi Okamoto Marcus Kaul Ian Paul Everall and Eliezer Masliah * 4.5. HIV-1 and cannabinoids Guy A. Cabral and Erinn S. Raborn * 4.6. HIV-1 and METH Howard S. Fox * 4.7. HIV-1 and Opioids Toby K. Eisenstein Jessica Breslow Changcheng Song Mathew J. Finley William D. Cornwell Sumedha Chugh Joseph J. Meissler and Thomas J. Rogers * 4.8. HIV-1 and Cocaine Shilpa J. Buch Honghong Yao and Sabita Roy * Section 5. Animal models * 5.1. SIV Janice E. Clements M. Christine Zink Joseph L. Mankowski David R. Graham and Lucio Gama * 5.2. FIV Rick B. Meeker * 5.3. CAEV Valgerdur Andrésdóttir Sigurbjörg Torsteinsdóttir and Gudmundur Georgsson * 5.4. Transgenics Sulie L. Chang and Marley D. Kass * 5.5. Immunodeficient mice Larisa Poluektova * 5.6. SIV and opiates Shilpa J. Buch Shannon Callen Paul Cheney and Anil Kumar * 5.7. SIV and FIV and peripheral neuropathy Joseph L. Mankowski Victoria A. Laast Gigi Ebenezer and Justin C. McArthur * 5.8. Animal models and bioimaging R. Gilberto González Eva-Maria Ratai and Margaret R. Lentz * Section 6. Personal Perspectives in Living with HIV/AIDS * 6.1. Darren Kane * 6.2. Eric Glare * 6.3. James May * 6.4. Karen * 6.5. Susan Paxton * Section 7. Clinical and Pathologic Manifestations of Disease * 7.1. Prospective on HIV CNS Infections Richard W. Price * 7.2. HAND Igor Grant and Ned Sacktor * 7.3. Early Manifestations of CNS Disease Serena S. Spudich * 7.4. HIV-1 Neuropathology Benjamin B. Gelman and David J. Moore * 7.5. Peripheral Neuropathy David M. Simpson Kathryn J. Elliott and Justin McArthur * 7.6. Spinal Cord Disease Christina M. Marra * 7.7. Myopathy Susan Morgello Jessica Robinson-Papp Kenneth A. Fox and David M. Simpson * 7.8. Aging Christian L. Achim and Virawudh Soontornniyomkij * 7.9. Addiction R. Douglas Bruce * Chapter 8. Pathogenesis of Co-Morbid Conditions * 8.1. NeuroAIDS as an Inflammatory Disorder Dennis L. Kolson Denise R. Cooka Stephanie A. Crossa and Samantha S. Soldana * 8.2. Neuronal Injury White Matter Disease and Neurotrophic Factors Dianne Langford Eliezer Masliah and Ian Paul Everall * 8.3. Pathobiology of HIV-related neuropathies BJ Brew and NWS Davies * 8.4. CNS Co-morbidities Georgette D. Kanmogne and David B. Clifford * 8.5. Opportunistic Infections Joseph R. Berger and Bruce A. Cohen * 8.6. PML Eugene O. Major and Maria Chiara G. Monaco * 8.7. Neoplasms Alexis Demopoulos and Lauren Abrey * 8.8. Hepatitis C Wenzhe Ho and Li Ye * 8.9. Psychiatric Co-Morbidities Ian Paul Everall and Timothy B. Nguyen * Chapter 9. Diagnostics and Biomarkers * 9.1. Brain Imaging Linda Chang Ute Feger and Thomas Ernst Ph.D. * 9.2. MRI Terry L. Jernigan Sarah L. Archibald and Christine Fennema-Notestine * 9.3. Psychological Evaluations Steven Paul Woods Jordan Elizabeth Cattie and Igor Grant * 9.4. Viral and Cellular Biomarkers During Antiretroviral Therapy Scott L. Letendre * 9.5. Viral Dynamics Ronald J. Ellis and Davey M. Smith * 9.6. Viral Clades Avindra Nath and Wenxue Li * 9.7. Proteomics and Biomarkers Pawel Ciborowski Gwenael Pottiez and Jayme Wiederin * Chapter 10. Children and Adolescents * 10.1. Clinical and Pathological Features of HIV-1 Encephalopathy in Children and Adolescents Mark Mintz Leroy Sharer and Lucy Civitello * 10.2. Infants Children and Adolescents Nervous System Disease in the era of combination antiretroviral therapy Annelies Van Rie and Anna Dow * 10.3. Psychosocial Aspects of Neurologic Impairment in Children with AIDS Lori Wiener and Claude Mellins * 10.4. Growing up with HIV Disease Lynnae Schwartz Leslie K. Serchuck and Shirley F. Delair * Chapter 11. Antiretroviral and Adjunctive Therapies * 11.1. Current Concepts in the Treatment of HIV Infection with Focus on Brain Disease Susan Swindells and Uriel Sandkovsky * 11.2. Pharmacology of Antiretroviral Therapies J. Allen McCutchan Scott Letendre Ronald J. Ellis Brookie Best and Edmund Capparelli * 11.3. Treatment of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection David B. Clifford * 11.4. Nanoformulated Medicines Howard E. Gendelman Upal Roy Shantanu Balkundi and JoEllyn McMillan * 11.5. Antiretroviral nanotherapies Madhavan P.N. Nair and Zainulabedin M. Saiyed * 11.6. Adjunctive Medicines Harris A. Gelbard and Stuart A. Lipton * Chapter 12. Psychiatry and Psychobiology * 12.1. Psychiatric Disorders J. Hampton Atkinson Nichole A. Duarte and Glenn Treisman * 12.2. Neuropsychiatry of Substance Abuse Eileen M. Martin-Thomas Andy Levine and Raul Gonzalez * 12.3. Psychobiology of Risk Behavior David G. Ostrow * 12.4. Everyday Impact of HIV-Associated Neurocognitive Disorders Thomas D. Marcotte J. Cobb Scott Charles H. Hinkin and Robert K. Heaton * 12.5. Facing Legal and Ethical Challenges in the Treatment of AIDS Glenn J. Treisman and Warren B. Treisman * 12.6. Neuropsychological Testing Kevin R. Robertson Kevin J. Liner Michelle Ro and Robert K. Heaton * 12.7. The impact of HIV subtype cultural and sociodemographic factors on HIV-1 infection and associated neuropathogenesis in Africa Adelina Holguin Damien C. Tully and Charles Wood
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