The OMICs (eBook, PDF)

Applications in Neuroscience
Redaktion: Coppola, Giovanni

• Format: PDF

Produktbeschreibung

The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience, and medicine in general. The book includes a rich survey of the most relevant OMICs applications and how they relate to neurology and neuroscience. The reader is given an overview of the method, a perspective on the current and future applications, and published examples illustrating practical uses.

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Produktdetails

• Verlag: Oxford University Press
• Seitenzahl: 272
• Erscheinungstermin: 11. Dezember 2013
• Englisch
• ISBN-13: 9780199354993
• Artikelnr.: 40761738

Autorenporträt

Giovanni Coppola, MD Assistant Professor Laboratory of Neurogenetics Department of Neurology, David Geffen School of Medicine

Inhaltsangabe

* Section 1. DNA
* Chapter 1: Medical DNA Sequencing in Neuroscience
* Chapter 2: Epigenomics: an Overview
* Chapter 3: The Role Of Epigenomics In Genetically Identical
Individuals
* Section 2. RNA
* Chapter 5: Decoding alternative mRNAs in the OMIC-age
* Chapter 6: Transcriptomics: from Differential Expression to
Coexpression
* Chapter 7: High-Throughput-RNA Interference As A Tool For Discovery
in Neuroscience
* Chapter 8: The Genetics Of Gene Expression: Multiple Layers and
Multiple Players
* Section 3. PROTEIN
* Chapter 9: Proteomics
* Chapter 10: Focused plasma proteomics for the study of brain aging
and neurodegeneration
* Section 4. CELLS AND CONNECTIONS
* Chapter 11: Cellomics: Characterization of Neuronal Subtypes by
High-Throughput Transgenic Mouse Models
* Chapter 12: Neuroscience and Metabolomics
* Chapter 13: Brain Connectomics in Man and Mouse
* Chapter 14: Optogenetics
* Chapter 15: Characterising the Gut Microbiome: Role in Brain-Gut
Function
* Section 5. THERAPEUTICS
* Chapter 16: OMICS in Drug Discovery: From Small Molecule Leads to
Clinical Candidates
* Chapter 17: Pharmacogenomics
* Section 6. OMICsOME: integration of OMICs data
* Chapter 18: Multidimensional Databases Of Animal Models
* Chapter 19: Network Biology and Molecular Medicine in the Post
Genomic Era: The Systems Pathobiology of Network Medicine