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The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of the rapidly developing field of pain research. As populations age, the number of people in pain is growing dramatically, with half the population living with pain. The opioid crisis has highlighted this problem. The present volume is thus very timely, providing expert overviews of many complex topics in pain research that are likely to be of interest not just to pain researchers, but also to pain clinicians who are seeking new therapeutic opportunities to develop analgesics. Many of the topics covered are…mehr
The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of the rapidly developing field of pain research. As populations age, the number of people in pain is growing dramatically, with half the population living with pain. The opioid crisis has highlighted this problem. The present volume is thus very timely, providing expert overviews of many complex topics in pain research that are likely to be of interest not just to pain researchers, but also to pain clinicians who are seeking new therapeutic opportunities to develop analgesics. Many of the topics covered are of interest to neuroscientists, as pain is one of the most amenable sensations for mechanistic dissection. The present volume covers all aspects of the topic, from a history of pain through invertebrate model systems to the human genetics of pain and functional imaging. Chapters include the role of ion channels, the opioid system, the immune and sympathetic systems, as well as the mechanisms that transform acute to chronic pain. Migraine and the interplay between sleep and pain are also discussed. New technology in the form of transgenic animals, chemogenetics, optogenetics, and proteomic analyses are providing significant advances in our research and are covered as well. Demystifying pain through an understanding of its fundamental biology, as outlined in this volume, is the most direct route to ameliorating this vast human problem.
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John Wood completed a PhD at Warwick University and trained as a virologist with Luc Montagnier in Paris. After 12 years in industry, he began his career in pain research at University College London. He focused on genetic approaches to pain mechanisms, identifying transcripts uniquely expressed by sensory neurons, including sodium channels involved in the transmission of nociceptive information that eventually cause a sensation of pain. In 2009 he won the Grand Prix Scientifique of the French Academy and became a Fellow of the Royal Society. He founded a start-up biotech company Ionix Pharmaceuticals to develop new analgesic drugs. More recently he has exploited mouse and human genetics to identify and validate new genes involved in pain pathways. He continues to explore the mechanisms involved in pain pathways and the development of new therapeutic strategies to treat chronic pain.
Inhaltsangabe
* About the Editor * Contributors * Preface * Acknowledgments * 1. A History of Pain Research * Fernando Cervero and John N. Wood * 2. The Measurement of Pain in the Laboratory Rodent * Jeffrey S. Mogil * 3. Invertebrate Models of Nociception: Learning From Flies and Worms * Daniel Hesselson, Denise S. Walker, Joshua Neil Massingham, William R. Schafer, G. Gregory Neely, and Yee Lian Chew * 4. Human Genetics of Pain * James J. Cox, Ingo Kurth, and C. Geoffrey Woods * 5. Dorsal Root Ganglion Neuron Types and Their Functional Specialization * Edward C. Emery and Patrik Ernfors * 6. The Sympathetic Nervous System and Pain * Judith A. Strong, Jun-Ming Zhang, and Hans-Georg Schaible * 7. Heat Pain and Cold Pain * Felix Viana and Thomas Voets * 8. Noxious Mechanosensation * Patrick Delmas, Sergiy Mikhailovych Korogod, and Bertrand Coste * 9. Sodium Channels and Pain * Theodore R. Cummins, Stephen G. Waxman, and John N. Wood * 10. Potassium Channels and Pain * Jérôme Busserolles, Xavier Gasull, and Jacques Noël * 11. Voltage Gated Calcium Channels: Molecular Targets for Treating Chronic Pain * Gerald W. Zamponi, Maria A. Gandini, and Terry P. Snutch * 12. Chloride Channels in Nociceptors * Uhtaek Oh and Jooyoung Jung * 13. Neuroimmune Interactions and Pain * Jiahe Li and Peter M. Grace * 14. The Neurobiology of Pain: Development and Sex * Maria Fitzgerald and Michael W. Salter * 15. Central Nervous System Pain Pathways * Andrew J. Todd and Fan Wang * 16. Dorsal Horn Pain Mechanisms * Hanns Ulrich Zeilhofer and Robert Ganley * 17. Visceral Pain * David C. Bulmer and Carolina Roza * 18. fMRI and Human Pain Perception * Giandomenico Iannetti and A. Vania Apkarian * 19. Neurobiological Basis of Migraine * Philip R. Holland, Jan Hoffmann, and Peter J. Goadsby * 20. Effect of Sleep Loss on Pain * Chloe Alexandre, Alban Latremoliere, and Patrick H. Finan * 21. Sensory Signaling Pathways in Inflammatory and Neuropathic Pain * Hanneke L.D.M. Willemen and Niels Eijkelkamp * 22. The Diversity of Neuropathic Pain * Nanna Brix Finnerup and Nadine Attal * 23. The Transition From Acute to Chronic Pain * Wei-Hsin Sun, Yu-Shiuan Su, and Chih-Cheng Chen * 24. Cancer and Pain * Rie Bager Hansen and Sarah Falk * 25. Opioids and Pain * Christoph Stein and Claire Gaveriaux-Ruff * 26. Neurotrophins, Cytokines, and Pain * Shafaq Sikandar and Claudia Sommer * 27. Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways * Sascha R.A. Alles, Anne-Marie Malfait, and Richard J. Miller * 28. Autoantibodies and Neuropathic Pain * John M. Dawes and David L. Bennett * 29. The Proteomics and Metabolomics of Pain - Opportunities for Systems Medicine * David Gomez-Varela and Manuela Schmidt * Index
* About the Editor * Contributors * Preface * Acknowledgments * 1. A History of Pain Research * Fernando Cervero and John N. Wood * 2. The Measurement of Pain in the Laboratory Rodent * Jeffrey S. Mogil * 3. Invertebrate Models of Nociception: Learning From Flies and Worms * Daniel Hesselson, Denise S. Walker, Joshua Neil Massingham, William R. Schafer, G. Gregory Neely, and Yee Lian Chew * 4. Human Genetics of Pain * James J. Cox, Ingo Kurth, and C. Geoffrey Woods * 5. Dorsal Root Ganglion Neuron Types and Their Functional Specialization * Edward C. Emery and Patrik Ernfors * 6. The Sympathetic Nervous System and Pain * Judith A. Strong, Jun-Ming Zhang, and Hans-Georg Schaible * 7. Heat Pain and Cold Pain * Felix Viana and Thomas Voets * 8. Noxious Mechanosensation * Patrick Delmas, Sergiy Mikhailovych Korogod, and Bertrand Coste * 9. Sodium Channels and Pain * Theodore R. Cummins, Stephen G. Waxman, and John N. Wood * 10. Potassium Channels and Pain * Jérôme Busserolles, Xavier Gasull, and Jacques Noël * 11. Voltage Gated Calcium Channels: Molecular Targets for Treating Chronic Pain * Gerald W. Zamponi, Maria A. Gandini, and Terry P. Snutch * 12. Chloride Channels in Nociceptors * Uhtaek Oh and Jooyoung Jung * 13. Neuroimmune Interactions and Pain * Jiahe Li and Peter M. Grace * 14. The Neurobiology of Pain: Development and Sex * Maria Fitzgerald and Michael W. Salter * 15. Central Nervous System Pain Pathways * Andrew J. Todd and Fan Wang * 16. Dorsal Horn Pain Mechanisms * Hanns Ulrich Zeilhofer and Robert Ganley * 17. Visceral Pain * David C. Bulmer and Carolina Roza * 18. fMRI and Human Pain Perception * Giandomenico Iannetti and A. Vania Apkarian * 19. Neurobiological Basis of Migraine * Philip R. Holland, Jan Hoffmann, and Peter J. Goadsby * 20. Effect of Sleep Loss on Pain * Chloe Alexandre, Alban Latremoliere, and Patrick H. Finan * 21. Sensory Signaling Pathways in Inflammatory and Neuropathic Pain * Hanneke L.D.M. Willemen and Niels Eijkelkamp * 22. The Diversity of Neuropathic Pain * Nanna Brix Finnerup and Nadine Attal * 23. The Transition From Acute to Chronic Pain * Wei-Hsin Sun, Yu-Shiuan Su, and Chih-Cheng Chen * 24. Cancer and Pain * Rie Bager Hansen and Sarah Falk * 25. Opioids and Pain * Christoph Stein and Claire Gaveriaux-Ruff * 26. Neurotrophins, Cytokines, and Pain * Shafaq Sikandar and Claudia Sommer * 27. Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways * Sascha R.A. Alles, Anne-Marie Malfait, and Richard J. Miller * 28. Autoantibodies and Neuropathic Pain * John M. Dawes and David L. Bennett * 29. The Proteomics and Metabolomics of Pain - Opportunities for Systems Medicine * David Gomez-Varela and Manuela Schmidt * Index
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