An Integrated Textbook of Basic Science, Medicine, and Surgery Redaktion: Beger, Hans G.; Zhao, Yupei; Whitcomb, David C.; Warshaw, Andrew L.; Shimosegawa, Tooru; Neoptolemos, John P.; Mayerle, Julia; Hruban, Ralph H.; Buchler, Markus W.
An Integrated Textbook of Basic Science, Medicine, and Surgery Redaktion: Beger, Hans G.; Zhao, Yupei; Whitcomb, David C.; Warshaw, Andrew L.; Shimosegawa, Tooru; Neoptolemos, John P.; Mayerle, Julia; Hruban, Ralph H.; Buchler, Markus W.
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The PANCREAS The newest edition of the essential guide to pancreatic medicine The fourth edition of The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery integrates the cutting-edge research of recent years to update its presentation of this fast-growing subject. It details every known disorder of the pancreas, grounding them in a thorough understanding of pancreatic function, enhanced with high quality illustration and graphs. It also includes step-by-step guidance for relevant endoscopic techniques and surgical procedures. The Pancreas readers will also find: * New…mehr
The PANCREAS The newest edition of the essential guide to pancreatic medicine The fourth edition of The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery integrates the cutting-edge research of recent years to update its presentation of this fast-growing subject. It details every known disorder of the pancreas, grounding them in a thorough understanding of pancreatic function, enhanced with high quality illustration and graphs. It also includes step-by-step guidance for relevant endoscopic techniques and surgical procedures. The Pancreas readers will also find: * New comprehensive insights into three pancreatic diseases: autoimmune pancreatitis, cystic neoplasms, and neuroendocrine tumors * An editorial team with decades of clinical and research experience in the US, Europe, and Asia * Over 500 downloadable illustrations for use in scientific presentations The Pancreas is a foundational reference for clinicians and researchers in gastroenterology and gastrointestinal surgery.
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Autorenporträt
Hans G. Beger, MD, FACS (Hon.), JSS (Hon.), CSS (Hon.), Professor Emeritus of Surgery, University of Ulm, Ulm, Germany. Markus W. Büchler, MD, FACS (Hon.), FRCS (Hon.), FASA (Hon.) Professor of Surgery, University of Heidelberg, Heidelberg, Germany. Ralph H. Hruban, MD, Baxley Professor and Director, Department of Pathology and Director of the Sol Goldman Pancreatic Research Center, Johns Hopkins University School of Medicine, Baltimore, USA. Julia Mayerle, MD, Professor of Internal Medicine, Gastroenterology and Hepatology, Chair Department of Medicine II, LMU Klinikum, Ludwig-Maximilians-University, Munich, Germany. John P. Neoptolemos, MA, MB, BCHIR, MD FRCS, FMEDSCI, MAE Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany. Tooru Shimosegawa, MD, PhD, Professor Emeritus Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. Andrew L. Warshaw, MD, FACS, FRCSEd (Hon.), W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, and Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, USA. David C. Whitcomb, MD, PhD, Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh and UPMC, Pennsylvania, USA. Yupei Zhao, MD, FICS (Hon.), FACS (Hon.), FRCS (Engl) (Hon.), FCSHK (Hon.), Professor of Surgery, Department of General Surgery, Peking Union Medical College Hospital, Beijing, P.R. China.
Inhaltsangabe
About the Companion Website xvii
Section 1 Anatomy of the Pancreas 1
1 Development of the Pancreas and Related Structures 3 Brian Lewis and Junhao Mao
2 Anatomy, Histology, and Fine Structure of the Pancreas 9 Daniel S. Longnecker and Elizabeth D. Thompson
3 Congenital and Inherited Anomalies of the Pancreas 23 Heiko Witt and Martin Zenker
Section 2 Physiology and Pathophysiology of Pancreatic Functions 33
4 Physiology of Acinar Cell Secretion 35 Ole H. Petersen
5 Physiology of Duct Cell Secretion 48 Wei- Yin Lin, Paramita Sarkar, and Shmuel Muallem
6 Physiology and Pathophysiology of Function of Sphincter of Oddi 56 Savio George Barreto and James Toouli
7 Neurohormonal and Hormonal Control of Pancreatic Secretion 65 Chung Owyang and Matthew J. DiMagno
8 Regulation of Pancreatic Protein Synthesis and Growth 75 Maria Dolors Sans and John A. Williams
9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells 86 Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson
10 Pancreatic Endocrine-Exocrine Relationship 98 Kenichiro Furuyama and Yoshiya Kawaguchi
Section 3 Acute Pancreatitis 105
11 Epidemiology and Etiology of Alcohol- Induced Pancreatitis 107 Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte
12 Epidemiology and Etiology of Biliary Acute Pancreatitis 119 Ippei Ikoma, Ko Tomishima, and Hiroyuki Isayama
13 Genetic Factors in Acute Pancreatitis 128 Mitchell L. Ramsey and Georgios I. Papachristou
14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis 138 Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor
15 The Role of Neurogenic Inflammation in Pancreatitis 146 Metrah Mohammad Nader and Jami L. Saloman
16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis 155 Ujjwal M. Mahajan, F. Ulrich Weiss, Markus M. Lerch, and Julia Mayerle
17 Histopathology of Acute Pancreatitis 164 Günter Klöppel
18 Severity Classification of Acute Pancreatitis 170 John A. Windsor
19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 176 Bettina M. Rau and Claus Schäfer
20 Acute Pancreatitis Associated with Congenital Anomalies 185 Charlotte S. Austin, Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit
21 Acute Pancreatitis in Children 191 Mark E. Lowe and Véronique D. Morinville
22 Acute Pancreatitis Associated with Metabolic, Infections and Drug- Related Diseases 199 Ali A. Aghdassi, Mats L. Wiese, Quang Trung Tran, and Markus M. Lerch
23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 208 Yoshihisa Tsuji
24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 222 Steven M. Hadley, Jr. and Timothy B. Gardner
25 ICU Treatment of Severe Acute Pancreatitis 230 Scott R. Gunn and David C. Whitcomb
26 Clinical Course and Medical Treatment of Acute Pancreatitis-- Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 238 Rainer Isenmann and Mathias Wittau
27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 244 Lily V. Saadat and Thomas E. Clancy
28 Management of Infected Necrosis: Step- Up Approach 254 Hester C. Timmerhuis, Marc G. Besselink, and Hjalmar C. van Santvoort
29 Management of Infected Pancreatic Necroses: An Endoscopic Approach 260 Todd H. Baron
30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 266 Kulbir Mann and Michael G.T. Raraty &
1 Development of the Pancreas and Related Structures 3 Brian Lewis and Junhao Mao
2 Anatomy, Histology, and Fine Structure of the Pancreas 9 Daniel S. Longnecker and Elizabeth D. Thompson
3 Congenital and Inherited Anomalies of the Pancreas 23 Heiko Witt and Martin Zenker
Section 2 Physiology and Pathophysiology of Pancreatic Functions 33
4 Physiology of Acinar Cell Secretion 35 Ole H. Petersen
5 Physiology of Duct Cell Secretion 48 Wei- Yin Lin, Paramita Sarkar, and Shmuel Muallem
6 Physiology and Pathophysiology of Function of Sphincter of Oddi 56 Savio George Barreto and James Toouli
7 Neurohormonal and Hormonal Control of Pancreatic Secretion 65 Chung Owyang and Matthew J. DiMagno
8 Regulation of Pancreatic Protein Synthesis and Growth 75 Maria Dolors Sans and John A. Williams
9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells 86 Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson
10 Pancreatic Endocrine-Exocrine Relationship 98 Kenichiro Furuyama and Yoshiya Kawaguchi
Section 3 Acute Pancreatitis 105
11 Epidemiology and Etiology of Alcohol- Induced Pancreatitis 107 Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte
12 Epidemiology and Etiology of Biliary Acute Pancreatitis 119 Ippei Ikoma, Ko Tomishima, and Hiroyuki Isayama
13 Genetic Factors in Acute Pancreatitis 128 Mitchell L. Ramsey and Georgios I. Papachristou
14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis 138 Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor
15 The Role of Neurogenic Inflammation in Pancreatitis 146 Metrah Mohammad Nader and Jami L. Saloman
16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis 155 Ujjwal M. Mahajan, F. Ulrich Weiss, Markus M. Lerch, and Julia Mayerle
17 Histopathology of Acute Pancreatitis 164 Günter Klöppel
18 Severity Classification of Acute Pancreatitis 170 John A. Windsor
19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 176 Bettina M. Rau and Claus Schäfer
20 Acute Pancreatitis Associated with Congenital Anomalies 185 Charlotte S. Austin, Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit
21 Acute Pancreatitis in Children 191 Mark E. Lowe and Véronique D. Morinville
22 Acute Pancreatitis Associated with Metabolic, Infections and Drug- Related Diseases 199 Ali A. Aghdassi, Mats L. Wiese, Quang Trung Tran, and Markus M. Lerch
23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 208 Yoshihisa Tsuji
24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 222 Steven M. Hadley, Jr. and Timothy B. Gardner
25 ICU Treatment of Severe Acute Pancreatitis 230 Scott R. Gunn and David C. Whitcomb
26 Clinical Course and Medical Treatment of Acute Pancreatitis-- Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 238 Rainer Isenmann and Mathias Wittau
27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 244 Lily V. Saadat and Thomas E. Clancy
28 Management of Infected Necrosis: Step- Up Approach 254 Hester C. Timmerhuis, Marc G. Besselink, and Hjalmar C. van Santvoort
29 Management of Infected Pancreatic Necroses: An Endoscopic Approach 260 Todd H. Baron
30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 266 Kulbir Mann and Michael G.T. Raraty &
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