The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism (eBook, PDF)

Redaktion: Mackness, Bharti; Paragh, György; Aviram, Michael; Mackness, Mike

• Format: PDF

Produktbeschreibung

In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up-to-date, state-of-the-art review of current paraoxonase research. The book details a unique and novel enzyme whose physiological/pathological function(s) are just starting to be revealed.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 325
• Erscheinungstermin: 26. Oktober 2007
• Englisch
• ISBN-13: 9781402065613
• Artikelnr.: 37357098

Inhaltsangabe

The Bert La Du Memorial Lecture.- Paraoxonases: An Historical Perspective.- PONs and Atherosclerosis.- Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form.- Paraoxonase-1 and Cardiovascular Disease.- Oxidative Stress & Antioxidants and PON1 in Health and Disease.- D-4F Increases Paraoxonase 1 Activity in HDL.- Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids.- The Role of PON2 and PON3 in Atherosclerosis and Related Traits.- Paraoxonase 1 and Postprandial Lipemia.- PON1 Genotypes and Coronary Heart Disease.- PON1 Structure.- Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents.- Stabilisation of Active Form of Natural Human PON1 Requires HPBP.- PONs in Disease other than Atherosclerosis.- Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection.- Age-Related Alterations in PON1.- PON and Toxicology.- Paraoxonase (PON1) and Organophosphate Toxicity.- Implications of Paraoxonase-1 (PON1) Activity and Polymorphisms on Biochemical and Clinical Outcomes in Workers Exposed to Pesticides.- PON-Genetics and Regulation.- Transcriptional Regulation of the Paraoxonase Genes.- Effect of Lipid Lowering Medications on PON1.- The Functional Consequences of Polymorphisms in the Human PON1 Gene.- Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans.- PONs Biochemistry.- PONs' Natural Substrates - The Key for their Physiological Roles.- Paraoxonases, Quorum Sensing, And Pseudomonas Aeruginosa.