The Peripheral T-Cell Lymphomas (eBook, ePUB)

Redaktion: O'Connor, Owen A.; Zinzani, Pier L.; Kim, Won Seog

• Format: ePub

Produktbeschreibung

THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group's unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: * Covers the biological basis, epidemiology, classification, and treatment of PTCL * Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL * Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation * Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations * Features contributions from the Chairs The T-Cell Lymphoma Forum: the world's largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 416
• Erscheinungstermin: 25. Februar 2021
• Englisch
• ISBN-13: 9781119671367
• Artikelnr.: 61289254

Autorenporträt

About the Editors Owen A. O'Connor, American Cancer Society Research Professor, Professor of Medicine, Department of Medicine, Division of Hematology and Oncology, Program for T-cell Lymphoma Research, Department of Microbiology, Immunology, and Cancer Research, University of Virginia Cancer Center, Charlottesville, VA, USA. Won Seog Kim, MD, PhD is Professor of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Pier Luigi Zinzani, MD, PhD is Professor of Hematology, Director of Lymphoma and CLL Unit, and Chief of Phase I clinical trials, Institute of Hematology, University of Bologna, Italy.

Inhaltsangabe

Contributors xix

About the Companion Website xxiii

Part I Biological Basis of the Peripheral T-cell Lymphomas 1

1 The Fundamentals of T-cell Lymphocyte Biology 3
Claudio Tripodo and Stefano A. Pileri

Introduction 3

General View of the Differentiation and Function of T Lymphocytes 3

The T-cell System as a Frame for Peripheral T-cell Lymphoma: Taking Plasticity into Account 5

Must Reads 7

References 7

2 Mechanisms of T-cell Lymphomagenesis 9
François Lemonnier, Philippe Gaulard and Laurence de Leval

Introduction 9

Oncogenic Events in the Transformation of T or Natural Killer Cells 9

Genetic Lesions 9

Deregulated Pathways in Peripheral T-cell Lymphoma Oncogenesis (Figure 2.1, Table 2.1) 10

Signaling Pathways 13

Cell-cycle Control 14

Immune Surveillance 14

Role of the Microenvironment in Peripheral T-cell Lymphoma 15

The Model of Angio-immunoblastic T-cell Lymphoma and T Follicular Helper-derived Peripheral T-cell Lymphoma 15

Specific Microenvironment Components Present in Other Primary Cutaneous T-cell Lymphoma Entities 16

Underlying Factors Favoring the Tumor Transformation 18

Viruses 18

Chronic Antigenic Stimulation 19

Other Factors 19

Cell of Origin (Table 2.1) 20

Conclusion 22

Must Reads 22

References 22

3 Epigenetics of T-cell Lymphoma 27
H. Miles Prince, Jasmine Zain, Anas Younes, Sean Whittaker, Owen A. O'Connor and Sean Harrop

Introduction 27

Epigenetic Pathways Altered in T-cell Lymphoma 27

Epigenetic Changes Within Specific T-cell Lymphoma Subtypes 31

Peripheral T-cell Lymphoma Not Otherwise Specified 32

Angioimmunoblastic T-cell Lymphoma and Peripheral T-cell Lymphoma with T Follicular Helper Phenotype 32

Anaplastic Large-cell Lymphoma 33

Adult T-cell Leukemia/Lymphoma 33

Intestinal T-cell Lymphoma 34

Hepatosplenic T-cell Lymphomas 34

Extranodal Natural Killer/T-cell Lymphoma 34

Mycosis Fungoides and Sézary Syndrome 35

Established and Emerging Drugs Targeting the T-cell Lymphoma Epigenome 35

DNA Methyltransferase Inhibitors 35

Isocitrate Dehydrogenase Inhibitors 36

EZH2 Inhibitors 37

BET Inhibitors 38

Protein Arginine Methyltransferases Inhibitors 38

Combination Therapies Involving Epigenetic Targeting Agents 38

Future Directions 38

Must Reads 39

References 39

4 Animal Models of T-cell Lymphoma 47
Keiichiro Hattori, Raksha Shrestha, Tatsuhiro Sakamoto, Manabu Kusakabe and Mamiko Sakata-Yanagimoto

Introduction 47

Angioimmunoblastic T-cell Lymphoma 50

The ROQUIN Mouse Model 50

The Mouse Models Recapitulating Human Angioimmunoblastic T-cell Lymphoma Genomic Features 50

Tet2 Gene Trap Mice 50

G17V RHOA Mouse Model 50

PDX Models of Angioimmunoblastic T-cell Lymphoma 51

Anaplastic Large T-cell Lymphoma 51

Viral and Chimeric Models 51

Transgenic Models 51

CRISPR-Based Models 52

PDX Models of Anaplastic Large-Cell Lymphomas 52

Human T-cell Lymphotropic Virus Type 1 Adult T-cell Leukemia/Lymphoma 52

Mice Expressing HTLV-1 Viral Proteins 52

PDX Models of Adult T-cell Leukemia/Lymphoma 52

Cutaneous T-cell Lymphoma 53

Enteropathy-associated T-cell Lymphoma 53

Conclusion 53

Must Reads 53

References 54

Part II Epide