No detailed description available for "The practice of Peptide Synthesis".
Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.
Die Herstellerinformationen sind derzeit nicht verfügbar.
Inhaltsangabe
I Introduction.- II Protecting Groups.- 1 Introduction of Amine Protecting Groups.- 2 Blocking of the ?-Carboxyl Group.- 3 Protection of Side Chain Functions.- III Activation and Coupling.- 1 The Acid Chloride Procedure.- 2 The Azide Process.- 3 Symmetrical Anhydrides.- 4 Mixed Anhydrides.- 5 Preparation of Active Esters.- 6 Coupling with Active Esters.- 7 Peptide Bond Formation with the Aid of Coupling Reagents.- IV Removal of Protecting Groups.- 1 Hydrogenation.- 2 Reduction with Sodium in Liquid Ammonia.- 3 Removal of the Phthalyl (Phthaloyl) Group by Hydrazinolysis.- 4 Acidolysis.- 5 Hydrolysis.- 6 Base Catalyzed Elimination.- 7 Nucleophilic Displacement.- 8 Iodolysis.- 9 Reduction of Methionine Sulfoxide Containing Peptides.- V Special Procedures.- 1 Ammonolysis of Esters.- 2 Transesterification.- 3 Cyclization.- 4 Polycondensation.- 5 Partial Synthesis.- VI Models for the Study of Racemization.- 1 Benzoyl-leucyl-glycine Ethyl Ester.- 2 The Anderson-Callahan Test.- 3 Acylation with Acetyl-l-isoleucine.- 4 The Izumiya-Muraoka Model.- 5 Synthesis and Enantioselective Enzymic Hydrolysis of Tetraalanine.- VII Reagents for Peptide Synthesis.- 1 tert-Butyl Azidoformate.- 2 1-Adamantyl Chlorocarbonate.- 3 1-Isobutyloxycarbonyl-2-isobutyloxy-1,2-dihydroquinoline (IIDQ).- 4 Diphenyl Phosphorazidate (Diphenylphosphoryl Azide, DPPA).- 5 3-Hydroxy-3,4-dihydroquinazoline-4-one (4-Hydroxyquinazoline 3-oxide).- 6 1-Hydroxybenzotriazole.- 7 Ethyl 2-hydroximino-2-cyanoacetate.- 8 1-Guanyl-3,5-dimethyl-pyrazole Nitrate.- VIII Appendix.- 1 Conversion of Dicyclohexylammonium Salts of Protected Amino Acids to the Free Acids.- 2 Preparation pf Analytical Samples.
I Introduction.- II Protecting Groups.- 1 Introduction of Amine Protecting Groups.- 2 Blocking of the ?-Carboxyl Group.- 3 Protection of Side Chain Functions.- III Activation and Coupling.- 1 The Acid Chloride Procedure.- 2 The Azide Process.- 3 Symmetrical Anhydrides.- 4 Mixed Anhydrides.- 5 Preparation of Active Esters.- 6 Coupling with Active Esters.- 7 Peptide Bond Formation with the Aid of Coupling Reagents.- IV Removal of Protecting Groups.- 1 Hydrogenation.- 2 Reduction with Sodium in Liquid Ammonia.- 3 Removal of the Phthalyl (Phthaloyl) Group by Hydrazinolysis.- 4 Acidolysis.- 5 Hydrolysis.- 6 Base Catalyzed Elimination.- 7 Nucleophilic Displacement.- 8 Iodolysis.- 9 Reduction of Methionine Sulfoxide Containing Peptides.- V Special Procedures.- 1 Ammonolysis of Esters.- 2 Transesterification.- 3 Cyclization.- 4 Polycondensation.- 5 Partial Synthesis.- VI Models for the Study of Racemization.- 1 Benzoyl-leucyl-glycine Ethyl Ester.- 2 The Anderson-Callahan Test.- 3 Acylation with Acetyl-l-isoleucine.- 4 The Izumiya-Muraoka Model.- 5 Synthesis and Enantioselective Enzymic Hydrolysis of Tetraalanine.- VII Reagents for Peptide Synthesis.- 1 tert-Butyl Azidoformate.- 2 1-Adamantyl Chlorocarbonate.- 3 1-Isobutyloxycarbonyl-2-isobutyloxy-1,2-dihydroquinoline (IIDQ).- 4 Diphenyl Phosphorazidate (Diphenylphosphoryl Azide, DPPA).- 5 3-Hydroxy-3,4-dihydroquinazoline-4-one (4-Hydroxyquinazoline 3-oxide).- 6 1-Hydroxybenzotriazole.- 7 Ethyl 2-hydroximino-2-cyanoacetate.- 8 1-Guanyl-3,5-dimethyl-pyrazole Nitrate.- VIII Appendix.- 1 Conversion of Dicyclohexylammonium Salts of Protected Amino Acids to the Free Acids.- 2 Preparation pf Analytical Samples.
Es gelten unsere Allgemeinen Geschäftsbedingungen: www.buecher.de/agb
Impressum
www.buecher.de ist ein Internetauftritt der buecher.de internetstores GmbH
Geschäftsführung: Monica Sawhney | Roland Kölbl | Günter Hilger
Sitz der Gesellschaft: Batheyer Straße 115 - 117, 58099 Hagen
Postanschrift: Bürgermeister-Wegele-Str. 12, 86167 Augsburg
Amtsgericht Hagen HRB 13257
Steuernummer: 321/5800/1497
USt-IdNr: DE450055826
