The Proteasome - Ubiquitin Protein Degradation Pathway (eBook, PDF)

Redaktion: Zwickl, Peter; Baumeister, Wolfgang

• Format: PDF

Produktbeschreibung

This volume gives a complete overview of the structure and function of the proteasome, its regulators and inhibitors, and its cellular importance, in conjunction with the ubiquitin system, for the degradation of regulatory proteins and the generation of immunogenic peptides. The topics range from the molecular evolution of the proteasome and its associated activators, the proteasome in the immune response, to proteasome inhibitors.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 208
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642594144
• Artikelnr.: 53292466

Inhaltsangabe

List of Contents.- Molecular Evolution of Proteasomes.- The 20S Proteasome.- Regulating the 26S Proteasome.- The 11S Regulators of 20S Proteasome Activity.- Immunological Functions of the Proteasome.- Natural Substrates of the Proteasome and Their Recognition by the Ubiquitin System.- The Intracellular Localization of the Proteasome.- Proteasome Inhibitors: Complex Tools for a Complex Enzyme.