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The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals - specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.
The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals - specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.
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Norbert Voelkel and Sharon Rounds are the authors of The Pulmonary Endothelium: Function in Health and Disease, published by Wiley.
Inhaltsangabe
List of Contributors xi Introduction xvii Sharon Rounds and Norbert Voelkel Section I: Normal Pulmonary Endothelium. Structure, Function, Cell Biology 1 1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis 3 Margaret A. Schwarz and Ondine B. Cleaver 2: Anatomy of the Pulmonary Endothelium 25 Radu V. Stan 3: Cadherins and Connexins in Pulmonary Endothelial Function 33 Kaushik Parthasarathi and Sadiqa K. Quadri 4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix 51 Katie L. Grinnell and Elizabeth O. Harrington 5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function 73 Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta 6: Pulmonary Endothelium and Nitric Oxide 89 Yunchao Su and Edward R. Block 7: Pulmonary Endothelial Cell Surface Metabolic Functions 105 Usamah S. Kayyali and Barry L. Fanburg 8: Cell Biology of Lung Endothelial Permeability 113 Guochang Hu and Richard D. Minshall 9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels 129 Donna L. Cioffi, Songwei Wu and Troy Stevens 10: Pulmonary Endothelial Interactions with Leukocytes and Platelets 143 Rosana Souza Rodrigues and Guy A. Zimmerman 11: Mesenchymal-Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation 167 Kurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid 12: Pulmonary Endothelium and Vasomotor Control 185 Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta 13: Pulmonary Endothelial Progenitor Cells 203 Bernard Thébaud and Mervin C. Yoder 14: Bronchial Vasculature: The Other Pulmonary Circulation 217 Elizabeth Wagner 15: Mapping Protein Expression on Pulmonary Vascular Endothelium 229 Kerri A. Massey and Jan E. Schnitzer Section II: Mechanisms and Consequences of Pulmonary Endothelial Cell Injury 241 16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis 243 Qing Lu and Sharon Rounds 17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium 261 Kenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher 18: Hypoxia and the Pulmonary Endothelium 287 Matthew Jankowich, Gaurav Choudhary and Sharon Rounds 19: Viral Infection and Pulmonary Endothelial Cells 303 Norbert F. Voelkel 20: Effects of Pressure and Flow on the Pulmonary Endothelium 309 Wolfgang M. Kuebler 21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability 337 Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia 22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium 355 Vladimir R. Muzykantov Section III: Pulmonary Endothelium In Disease 379 23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn 381 Yuansheng Gao and J. Usha Raj 24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung 399 Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia 25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis 417 Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel 26: Role of the Endothelium in Emphysema: Emphysema - A Lung Microvascular Disease 437 Norbert F. Voelkel and Ramesh Natarajan 27: Pulmonary Endothelium and Pulmonary Hypertension 449 Rubin M. Tuder and Serpil C. Erzurum 28: Collagen Vascular Diseases and Pulmonary Endothelium 461 Pradeep R. Rai and Carlyne D. Cool 29: Pulmonary Endothelium in Thromboembolism 471 Irene M. Lang 30: Pulmonary Endothelium and Malignancies 485 Abu-Bakr Al-Mehdi Epilogue Norbert F. Voelkel Index 495
List of Contributors xi Introduction xvii Sharon Rounds and Norbert Voelkel Section I: Normal Pulmonary Endothelium. Structure, Function, Cell Biology 1 1: Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis 3 Margaret A. Schwarz and Ondine B. Cleaver 2: Anatomy of the Pulmonary Endothelium 25 Radu V. Stan 3: Cadherins and Connexins in Pulmonary Endothelial Function 33 Kaushik Parthasarathi and Sadiqa K. Quadri 4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix 51 Katie L. Grinnell and Elizabeth O. Harrington 5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular Barrier Function 73 Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta 6: Pulmonary Endothelium and Nitric Oxide 89 Yunchao Su and Edward R. Block 7: Pulmonary Endothelial Cell Surface Metabolic Functions 105 Usamah S. Kayyali and Barry L. Fanburg 8: Cell Biology of Lung Endothelial Permeability 113 Guochang Hu and Richard D. Minshall 9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels 129 Donna L. Cioffi, Songwei Wu and Troy Stevens 10: Pulmonary Endothelial Interactions with Leukocytes and Platelets 143 Rosana Souza Rodrigues and Guy A. Zimmerman 11: Mesenchymal-Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation 167 Kurt R. Stenmark, Evgenia V. Gerasimovskaya, Neil Davie and Maria Frid 12: Pulmonary Endothelium and Vasomotor Control 185 Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta 13: Pulmonary Endothelial Progenitor Cells 203 Bernard Thébaud and Mervin C. Yoder 14: Bronchial Vasculature: The Other Pulmonary Circulation 217 Elizabeth Wagner 15: Mapping Protein Expression on Pulmonary Vascular Endothelium 229 Kerri A. Massey and Jan E. Schnitzer Section II: Mechanisms and Consequences of Pulmonary Endothelial Cell Injury 241 16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis 243 Qing Lu and Sharon Rounds 17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium 261 Kenneth E. Chapman, Shampa Chatterjee and Aron B. Fisher 18: Hypoxia and the Pulmonary Endothelium 287 Matthew Jankowich, Gaurav Choudhary and Sharon Rounds 19: Viral Infection and Pulmonary Endothelial Cells 303 Norbert F. Voelkel 20: Effects of Pressure and Flow on the Pulmonary Endothelium 309 Wolfgang M. Kuebler 21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability 337 Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia 22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium 355 Vladimir R. Muzykantov Section III: Pulmonary Endothelium In Disease 379 23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn 381 Yuansheng Gao and J. Usha Raj 24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung 399 Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia 25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis 417 Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel 26: Role of the Endothelium in Emphysema: Emphysema - A Lung Microvascular Disease 437 Norbert F. Voelkel and Ramesh Natarajan 27: Pulmonary Endothelium and Pulmonary Hypertension 449 Rubin M. Tuder and Serpil C. Erzurum 28: Collagen Vascular Diseases and Pulmonary Endothelium 461 Pradeep R. Rai and Carlyne D. Cool 29: Pulmonary Endothelium in Thromboembolism 471 Irene M. Lang 30: Pulmonary Endothelium and Malignancies 485 Abu-Bakr Al-Mehdi Epilogue Norbert F. Voelkel Index 495
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