The Structure of Biological Membranes (eBook, PDF)

Redaktion: Yeagle, Philip L.

• Format: PDF

Produktbeschreibung

Completely revised and updated to reflect advances in the study of biological membranes, this third edition provides an integrated view of membrane structure and function. Introductory chapters focus on the fundamentals of lipid bilayers and membrane proteins for those new to the field. The second part of the book presents in-depth analyses of current topics, including the phase behavior of lipid bilayers; cholesterol's role in cell biology; the lateral organization of membranes; the role of lipids in membrane protein folding; membrane protein synthesis, stability, and transport; and interactions between proteins and lipids. It offers a valuable resource for researchers and students alike.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 398
• Erscheinungstermin: 18. Juli 2011
• Englisch
• ISBN-13: 9781439809587
• Artikelnr.: 57533898

Autorenporträt

Philip L. Yeagle is dean of the Faculty of Arts and Sciences and chief academic research officer at Rutgers University, Newark, New Jersey. He obtained his PhD at Duke University in 1974. As a postdoctoral fellow at the University of Virginia, he started his studies of membrane structure and dynamics, supported by an NIH postdoctoral fellowship. There he was one of the first investigators to discover and exploit the opportunities for 31P NMR studies of model and biological membranes. He began his faculty career in the School of Medicine, University at Buffalo, supported by an NIH RCDA, during which time he was able to define the molecular basis of an essential role of cholesterol in mammalian cell membranes. In 1985, he was a visiting scientist at the CSIRO, New South Wales, Australia, and in 1988 he developed the first in a series of FASEB Summer Research Conferences on membrane structure. In 1993, and again in 2003, he was a visiting professor in the Department of Biochemistry, University of Oxford. He moved in 1997 to the Department of Molecular and Cell Biology at the University of Connecticut as head of department and pursued studies of membrane protein structure. He was elected member of the Council of the Biophysical Society and chair of the Membrane Structure and Assembly subgroup that he helped form. He was executive editor of Biochemica et Biophysica Acta Biomembranes for a decade and a member of the editorial board of the Journal of Biological Chemistry. He has published over 150 papers and reviews and is the author or editor of seven books.

Inhaltsangabe

Introduction to Lipid Bilayers. Membrane Proteins. Introduction to
Lipid-Protein Interactions in Biological Membranes. The Mesomorphic Phase
Behavior of Lipid Bilayers. IR Spectroscopy of Lipid Chains: Theoretical
Background and Applications to Phase Transitions, Membranes, Cells, and
Tissues. The Roles of Cholesterol in the Biology of Cells. Functional
Consequences of the Lateral Organization of Biological Membranes.
Mechanisms by Which Pathogens Hijack and Utilize Membrane Domains to
Mediate Cytotoxicity. Lipid-Assisted Membrane Protein Folding and
Topogenesis. Membrane Protein Biogenesis and Assembly at the Endoplasmic
Reticulum Membrane. Thermal Denaturation of Membrane Proteins. Mass Action
Kinetic Analysis of Multidrug Resistance Transporters Expressed in
Confluent Cell Monolayers. How to Understand Lipid-Protein Interactions in
Biological Membranes. Biogenesis of Lipids and Proteins within
Mitochondrial Membranes. Index.