The Thermodynamic Machinery of Life (eBook, PDF) - Kurzynski, Michal
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Thermodynamics was created in the ?rst half of the 19th century as a theory designed to explain the functioning of heat engines converting heat into mechanical work. In the course of time, while the scope of research in this ?eld was being extended to a wider and wider class of energy transformations, thermodynamics came to be considered as a general theory of machines identi?ed with energy transducers. Imp- tant progress in biochemistry in the ?rst half of the 20th century, and in molecular biology in the second half, made it possible to think of treating even living organisms as machines, at…mehr

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Produktbeschreibung
Thermodynamics was created in the ?rst half of the 19th century as a theory designed to explain the functioning of heat engines converting heat into mechanical work. In the course of time, while the scope of research in this ?eld was being extended to a wider and wider class of energy transformations, thermodynamics came to be considered as a general theory of machines identi?ed with energy transducers. Imp- tant progress in biochemistry in the ?rst half of the 20th century, and in molecular biology in the second half, made it possible to think of treating even living organisms as machines, at least on the subcellular level. However, success in applying thermodynamics to elucidate the phenomenon of life has been rather mitigated. Two reasons seem to be responsible for this unsatisfactory s- uation. Nineteenth century thermodynamics dealt only with simple (homogeneous) systems in complete equilibrium. Although during the 20th century a nonequilibrium thermodynamics was developed, sta- ing with the Onsager theory of linear response and ending with the Prigogine nonlinear theory of dissipative structures, these theories still concern the originally homogeneous systems. Because living organisms are complex systems with a historically frozen spatial and functional structure, a thermodynamics of both nonequilibrium and complex s- tems is needed for their description. The ?rst goal of the present book is to formulate the foundations of such a thermodynamics.
Autorenporträt
The Thermodynamic Machinery of Life presents the relevant foundations of nonequilibrium thermodynamics as applied to biological processes taking place at the subcellular level. The biological cell is considered as a complex open thermodynamic system far from equilibrium that enzymatically controls various biochemical reactions and transport processes across internal and the cytoplasmatic membrane. The enzymatic free energy and signal transduction processes are described in detail. All the biological molecular machines, also pumps and motors are considered to be effective chemo-chemical free energy transducers. Special attention is paid to the role of the mesoscopic internal dynamics of biomolecules in the activity control of enzymes and the action of molecular machines.
Rezensionen
From the reviews:
"The book seamlessly presents the historical and philosophical evolution of a fundamental principle ... and develops the implications of the principle in a staggeringly wide range of contexts. ... a work that is engaging, lucid and supremely approachable. ... the warmth and sincerity of the writing make this book a joy ... . Highly recommended." (Philosophy, Religion and Science Book Reviews, bookinspections.wordpress.com, May, 2014)