Therapeutic Oligonucleotides (eBook, PDF)

Redaktion: Kurreck, Jens

• Format: PDF

Produktbeschreibung

This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. Written by leading expert scientists from both academia and leading biotechnical companies, the authors provide a compelling update on current status of RNA interference with emphasis on fascinating topics including oligonucleotides: antisense oligonucleotides, ribozymes, siRNAs, decoy oligonucleotides and aptamers. This exceptional work will be a valid resource for researchers and students as well as academia, consultants and scientists.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 362
• Erscheinungstermin: 22. April 2008
• Englisch
• ISBN-13: 9781847558275
• Artikelnr.: 44764289

Autorenporträt

Jens Kurreck is professor for nucleic acids technologies at the University of Stuttgart (Germany). He received his PhD at the Technical University Berlin in 1998 and was a postdoc at the Arizona State University in Tempe, USA. From 1999 to 2007 he was assistant professor ('Habilitand') at the Free University Berlin. Furthermore, he holds a master's degree in philosophy. His group has been working in the field of gene silencing for many years with a focus on pain research and heart muscle infections. In 2005, Jens Kurreck received the award for the best teaching at the biochemistry department as well as the Young Scientist Lectureship Award of the European Society for Neurochemistry (ESN).

Inhaltsangabe

Chapter 1: The Role of Backbone Modifications in Oligonucleotide-Based Strategies
Chapter 2: Genasense (G3139): An Antisense Bcl-2 Oligodeoxyribonucleotide with Substantial Clinical Activity and a Complex Mechanism of Action
Chapter 3: Antisense Morpholino Oligomers and Their Peptide Conjugates
Chapter 4: Peptide-PNA Conjugates for Modulation of Gene Expression
Chapter 5: Locked Nucleic Acid: Properties & Therapeutic Aspects
Chapter 6: Immune Stimulatory Oligonucleotides
Chapter 7: Decoy Oligonucleotides to Treat Inflammatory Diseases
Chapter 8: AS1411: Development of an Anticancer Aptamer
Chapter 9: Spielgelmer NOX-E36 for Renal Diseases
Chapter 10: Strategies for the Delivery of Oligonucleotides In Vivo
Chapter 11: Lipid-Mediated in vivo Delivery of Small Interfering RNAs
Chapter 12: Vector-Mediated and Viral Delivery of Short Hairpin RNAs
Chapter 13: Development of an RNAi Based Gene Therapy against HIV-1
Chapter 14: RNA Based Therapies for Treatment of HIV Infection