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* Provides a comprehensive update on therapies for Parkinson's disease and other movement disorders * Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management * Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions * The expert guidance of recognised authorities will enable readers of this book to plan their patients' care with greater confidence
* Provides a comprehensive update on therapies for Parkinson's disease and other movement disorders * Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management * Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions * The expert guidance of recognised authorities will enable readers of this book to plan their patients' care with greater confidence
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Autorenporträt
Mark Hallett, MD, Senior Investigator at National Institute of Neurological Disorders and Stroke (NINDS), Chief of the Medical Neurology Branch and Chief of Human Motor Control Section; Editor-in-Chief of Clinical Neurophysiology; Associate Editor of Brain. Werner Poewe, Chairman of the Department of Neurology at Medical University of Innsbruck; Editorial board member of Movement Disorder, Journal of Neurology, Journal of Neural Transmission, and Aktuelle Neurologie.
Inhaltsangabe
Preface ix Contributors xi Part I Parkinson's Disease and Parkinsonism 1 The Etiopathogenesis of Parkinson's Disease: Basic Mechanisms of Neurodegeneration 3 C. Warren Olanow and Kevin McNaught 2 Physiology of Parkinson's Disease 25 Shlomo Elias, Zvi Israel and Hagai Bergman 3 Pharmacology of Parkinson's Disease 37 Jonathan M. Brotchie 4 The Treatment of Early Parkinson's Disease 49 Olivier Rascol and Regina Katzenschlager 5 Treatment of Motor Complications in Advanced Parkinson's Disease 71 Susan H. Fox and Anthony E. Lang 6 Managing the Non-Motor Symptoms of Parkinson's Disease 91 Werner Poewe and Klaus Seppi 7 Surgery for Parkinson's Disease 121 Jens Volkmann 8 Future Cell- and Gene-Based Therapies for Parkinson's Disease 145 Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin 9 Parkinson-Plus Disorders 157 Martin Köllensperger and Gregor K. Wenning Part II Tremor Disorders 10 Essential Tremor 179 Rodger J. Elble 11 Other Tremor Disorders 193 Günther Deuschl Part III Dystonia, Cramps, and Spasms 12 Pathophysiology of Dystonia 205 Mark Hallett 13 General Management Approach to Dystonia 217 Cynthia L. Comella 14 Botulinum Toxin for Treatment of Dystonia 227 Dirk Dressler 15 Surgical Treatments of Dystonia 241 Christopher Kenney and Joseph Jankovic 16 Wilson's Disease 251 George J. Brewer 17 Cramps and Spasms 263 Christine D. Esper, Pratibha G. Aia, Leslie J. Cloud and Stewart A. Factor 18 Stiff Person Syndrome 283 Philip D. Thompson and Hans-Michael Meinck Part IV Chorea, Tics and other Movement Disorders 19 Huntington's Disease 295 Kevin M. Biglan and Ira Shoulson 20 Chorea 317 Francisco Cardoso 21 Treatment of Tics and Tourette Syndrome 331 Harvey S. Singer and Erika L.F. Hedderick 22 Therapeutics of Paroxysmal Dyskinesias 345 Shyamal H. Mehta and Kapil D. Sethi 23 Treatment of Miscellaneous Disorders 353 Marie Vidailhet, Emmanuel Roze and David Grabli 24 Myoclonus 363 Shu-Ching Hu, Steven J. Frucht and Hiroshi Shibasaki Part V Drug-induced Movement Disorders 25 Neuroleptic-Induced Movement Disorders 373 S. Elizabeth Zauber and Christopher G. Goetz 26 Other Drug-Induced Dyskinesias 389 Oscar S. Gershanik Part VI Ataxia and Disorders of Gait and Balance 27 Ataxia 407 Thomas Klockgether 28 Treatment of Gait and Balance Disorders 417 Bastiaan R. Bloem, Alexander C. Geurts, S. Hassin-Baer and Nir Giladi Part VII Restless Legs Syndrome 29 The Restless Legs Syndrome 447 Richard P. Allen and Birgit HEURogl Part VIII Pediatric Movement Disorders 30 Pediatric Movement Disorders 471 Jonathan W. Mink Part IX Psychogenic Movement Disorders 31 Psychogenic Movement Disorders 479 Elizabeth Peckham and Mark Hallett Index 489
Preface ix Contributors xi Part I Parkinson's Disease and Parkinsonism 1 The Etiopathogenesis of Parkinson's Disease: Basic Mechanisms of Neurodegeneration 3 C. Warren Olanow and Kevin McNaught 2 Physiology of Parkinson's Disease 25 Shlomo Elias, Zvi Israel and Hagai Bergman 3 Pharmacology of Parkinson's Disease 37 Jonathan M. Brotchie 4 The Treatment of Early Parkinson's Disease 49 Olivier Rascol and Regina Katzenschlager 5 Treatment of Motor Complications in Advanced Parkinson's Disease 71 Susan H. Fox and Anthony E. Lang 6 Managing the Non-Motor Symptoms of Parkinson's Disease 91 Werner Poewe and Klaus Seppi 7 Surgery for Parkinson's Disease 121 Jens Volkmann 8 Future Cell- and Gene-Based Therapies for Parkinson's Disease 145 Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin 9 Parkinson-Plus Disorders 157 Martin Köllensperger and Gregor K. Wenning Part II Tremor Disorders 10 Essential Tremor 179 Rodger J. Elble 11 Other Tremor Disorders 193 Günther Deuschl Part III Dystonia, Cramps, and Spasms 12 Pathophysiology of Dystonia 205 Mark Hallett 13 General Management Approach to Dystonia 217 Cynthia L. Comella 14 Botulinum Toxin for Treatment of Dystonia 227 Dirk Dressler 15 Surgical Treatments of Dystonia 241 Christopher Kenney and Joseph Jankovic 16 Wilson's Disease 251 George J. Brewer 17 Cramps and Spasms 263 Christine D. Esper, Pratibha G. Aia, Leslie J. Cloud and Stewart A. Factor 18 Stiff Person Syndrome 283 Philip D. Thompson and Hans-Michael Meinck Part IV Chorea, Tics and other Movement Disorders 19 Huntington's Disease 295 Kevin M. Biglan and Ira Shoulson 20 Chorea 317 Francisco Cardoso 21 Treatment of Tics and Tourette Syndrome 331 Harvey S. Singer and Erika L.F. Hedderick 22 Therapeutics of Paroxysmal Dyskinesias 345 Shyamal H. Mehta and Kapil D. Sethi 23 Treatment of Miscellaneous Disorders 353 Marie Vidailhet, Emmanuel Roze and David Grabli 24 Myoclonus 363 Shu-Ching Hu, Steven J. Frucht and Hiroshi Shibasaki Part V Drug-induced Movement Disorders 25 Neuroleptic-Induced Movement Disorders 373 S. Elizabeth Zauber and Christopher G. Goetz 26 Other Drug-Induced Dyskinesias 389 Oscar S. Gershanik Part VI Ataxia and Disorders of Gait and Balance 27 Ataxia 407 Thomas Klockgether 28 Treatment of Gait and Balance Disorders 417 Bastiaan R. Bloem, Alexander C. Geurts, S. Hassin-Baer and Nir Giladi Part VII Restless Legs Syndrome 29 The Restless Legs Syndrome 447 Richard P. Allen and Birgit HEURogl Part VIII Pediatric Movement Disorders 30 Pediatric Movement Disorders 471 Jonathan W. Mink Part IX Psychogenic Movement Disorders 31 Psychogenic Movement Disorders 479 Elizabeth Peckham and Mark Hallett Index 489
Rezensionen
"This book can be strongly recommended and is an asset to libraries of both movement disorder specialists and general neurologists. Its logical structure, linking therapy with underlying pathophysiology, means that it will remain a useful reference even as new therapies inevitably emerge." ( The Lancet Neurology , July 2009)
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