Therapy Resistance in Prostate Cancer (eBook, ePUB)

Mechanisms and Insights
Redaktion: Bahmad M. D., Hisham

• Format: ePub

Produktbeschreibung

Prostate cancer (PCa) is among the most diagnosed cancers in men worldwide as well as one of the most common causes of cancer-related deaths. Despite the advances in treatment, the disease remains associated with poor survival and resistance to cytotoxic and targeted therapies.

Therapy Resistance in Prostate Cancer: Mechanisms and Insights highlights the main mechanisms that are responsible for therapy resistance in PCa allowing researchers and clinicians to have a synopsis of current options and new therapies that can be proposed to overcome this resistance. Understanding the mechanisms responsible for chemotherapy resistance helps researchers all over the world to delve deeper into the pathways behind this resistance and potentially discover new therapeutic targets for PCa.

• Tackles the topic of resistance from a broader perspective, including, but not limited to, the role of the extracellular matrix and cancer stem cells in therapy resistance
• Creates understanding on how to develop novel therapies that specifically target CSCs to eliminate the regenerating capacity of the tumor and overcome therapy resistance
• Helps in identifying novel molecular biomarkers and potential therapeutic targets pertaining to the tumor microenvironment to overcome therapy resistance
• Provides a general view of the main pathways involved in PCa progression that will aid in understanding the mechanisms responsible for chemotherapy resistance

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 276
• Erscheinungstermin: 24. Oktober 2023
• Englisch
• ISBN-13: 9780443160332
• Artikelnr.: 69215619

Inhaltsangabe

1. Prostate Gland Anatomy and Hormonal Factors Contributing to Cancer
Development 2. Pathophysiology and Molecular Aberrations of Castration
Resistant Prostate Cancer 3. Role of Tumor Microenvironment in Prostate
Cancer Therapy Resistance 4. Androgen Receptor-Dependent Mechanisms
Mediating Therapy Resistance in Prostate Cancer 5. Epigenetic Changes
Driving Therapy Resistance in Prostate Cancer 6. Role of Cancer Stem Cells
in Prostate Cancer Therapy Resistance 7. Resistance to Taxane
Chemotherapies in Prostate Cancer 8. Resistance of Prostate Cancer to
Topoisomerase Inhibitors 9. Resistance of Prostate Cancer to Kinase
Inhibitors 10. Radioresistance Mechanisms in Prostate Cancer 11.
Immunotherapeutic Strategies and Immunotherapy Resistance in Prostate
Cancer 12. Overcoming Resistance in Prostate Cancer with Targeted and Small
Molecule-Based Therapies 13. Novel Treatment Strategies to Overcome
Resistance in Prostate Cancer