Thrombin (eBook, PDF)

Structure and Function
Redaktion: Berliner, Lawrence J.

• Format: PDF

Produktbeschreibung

Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombin topic areas: Structure, Biochemistry, and Physiology. In Part 1, Structure, we open with the complete three-dimensional x-ray structures of two inhibited human thrombin complexes, one of which is the thrombin-hirudin com plex. These complexes are also addressed in the chapter on structural studies in solution, which include NMR, ESR, and fluorescence. Part 2, Biochemistry, includes chapters on synthetic thrombin inhibitors, protein inhibitors (e.g., antithrombin III, hirudin), and thrombin interactions with factor XIII. Part 3, Physiology, covers such topics as chemotactic activities, interactions with cell surfaces, and the vascular endothelium.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 438
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781461532965
• Artikelnr.: 43988975

Autorenporträt

Dr. Lawrence J. Berliner is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for Biological Magnetic Resonance, which he launched in 1979.

Inhaltsangabe

1. Structure.- 1. X-Ray Crystal Structures of Human ?-Thrombin and of the Human Thrombin-Hirudin Complex.- 2. Nuclear Magnetic Resonance Studies of Thrombin-Fibrinopeptide and Thrombin-Hirudin Complexes.- 3. ESR and Fluorescence Studies of Thrombin Active Site Conformation.- 2. Biochemistry.- 4. Synthetic Substrates and Inhibitors of Thrombin.- 5. Regulation of Thrombin by Antithrombin and Heparin Cofactor II.- 6. Hirudin Interactions with Thrombin.- 7. Activation of Human Plasma Factor XIII by Thrombin.- 3. Physiology.- 8. Effect of Chemical Modification of ?-Thrombin on Its Reaction with Platelets and Nucleated Cells.- 9. Functional Domains in Thrombin outside the Catalytic Site: Cellular Interactions.- 10. Postclotting Cellular Effects of Thrombin Mediated by Interaction with High-Affinity Thrombin Receptors.- 11. Regulation of Thrombin-Induced Endothelial Barrier Dysfunction and Prostaglandin Synthesis.