Thymic Development and Selection of T Lymphocytes (eBook, PDF)

Redaktion: Boehm, Thomas; Takahama, Yousuke

• Format: PDF

Produktbeschreibung

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 132
• Erscheinungstermin: 6. November 2013
• Englisch
• ISBN-13: 9783642402524
• Artikelnr.: 43795694

Inhaltsangabe

Development and Function of Cortical Thymic Epithelial Cells.- Mechanisms of Thymus Medulla Development And Function.- Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function.- Central Tolerance Induction.- Trafficking to the Thymus.- The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.