A. Pinchera

Thyroid Autoimmunity (eBook, PDF)

• Format: PDF

Produktbeschreibung

In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 638
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781461309451
• Artikelnr.: 44044522

Inhaltsangabe

Graves' Disease: A Paradigm for Autoimmunity.- Nature of Thyroid Autoantigens: The TSH Receptor.- Progress in Understanding the Thyroid Microsomal Antigen.- A Possible Role of Bacterial Antigens in the Pathogenesis of Autoimmune Thyroid Disease.- "ATRA I": A New Autoantiaen in Autoimmune Thyroid Disease.- Monoclonal Antibodies in the Study of Thyroid Autoantigens and Autoantibodies.- LATS/TSAb: Then and Now.- Pathogenic Roles of TSH Receptor Antibodies in Graves' Disease.- Physlopathological Relevance of Thyroid Stimulating Antibody (TSAb) Measurements in Graves' Disease.- TSH Receptor Autoantibodies Affecting Thyroid Cell Function.- Heterogeneity of TSH Receptor-directed Antibodies (TRAb) and Their Significance.- Humoral Factors in Graves1 Ophthalmopathy.- Immunoregulatory Abnormalities in Autoimmune Thyroid Disease.- Intrathyroidal Lymphocytes, Thyroid Autoantibodies and Thyroid Destruction.- Cellular Mechanisms for Autoimmune Damage in Thyroid-Associated Ophthalmopathy.- Thyroid Infiltrating T Lymphocytes in Hashimoto's Thyroiditis: Phenotypic and Functional Analysis at Single Cell Level.- An in Vitro Model for Thyroid Autoimmunity.- Genetic Aspects of Graves' Disease.- Thyroid and Related Autoimmune Disorders: Challenging the Dogmas.- Molecular and Functional Characterization of Genes Encoding Anti-Thyroglobulin and Anti-TSH Receptor Antibodies.- Autoantigenicity of Murine Thyroglobulin.- IgG Subclass Distribution of Anti-Tg Antibodies among Thyroid Disease Patients and Their Relatives and in High and Low Responder Mouse Strains.- Genetic Basis of Spontaneous Autoimmune Thyroiditis.- Heterotransplantation of Autoimmune Human Thyroid to Nude Mice as a Tool for in Vivo Autoimmune Research.- Post-Partum Thyroid Dysfunction.- Autoimmune and AutonomousToxic Goiter; Differentiation and Clinical Outcome after Drug Treatment.- Postpartum Onset of Graves' Disease.- Thyrotropin-Binding Inhibitor Immunoglobulins in Primary Hypothyroidism.- Thyroid Function Modulates Thymic Endocrine Activity.- The BB/W Rat, a Model for "Tgl-associated Goitre".- Non-Thyroidal Complications of Graves' Disease: Perspective on Pathogenesis and Treatment.- Cross Reactivity between Antibodies to Human Thyroglobulin and Torpedo Acetylcholinesterase in Patients with Graves' Ophthalmopathy.- Multiple Autoantiqenic Determinants in Thyroid Autoimmunity.- Further Characterization of the Thyroid Microsomal Antigen by Monoclonal Antibodies.- Molecular Cloning of a Thyroid Peroxidase cDNA Fragment Encoding Epitopes Involved in Hashimoto's Thyroiditis iHT).- Further Evidence that Thyroid Peroxidase and "Microsomal Antigen" Are the Same Entity.- Competitive and Immunometric Radioassays for the Measurement of Anti-Thyroid Peroxidase Autoantibodies in Human Sera.- Thyroid Peroxidase and the "Microsomal Antigen", Cannot Be Distinguished by Immunofluorescence on Cultured Thyroid Cells.- Measurement of Anti-alpha-Galactosyl Antibodies in the Course of Various Thyroid Disorders and Isolation of an Antigenic Glycopeptide Fraction.- The IgG Subclass Distribution on Thyroid Autoantibodies in Graves' Disease.- Thyroid Hormone Binding Autoantibodies (THBA) in Humans and Animals.- High Frequency of Interferon-Gamma Producing T Cells in Thyroid Infiltrates of Patients with Hashimoto's Thyroiditis.- Lymphoklne Production and Functional Activities of T Cell Clones from Thyroid Gland of Hashimoto's Thyroiditis.- Circulatory Thyroglobulin Threshold in Suppressor Activation.- Thyroglobulin Autoantibody IgG Subclasses; Regulation by T Cells.-Cellular Immunity and Specific Defects of T-cell Suppression in Patients with Autoimmune Thyroid Disorders.- The Influence of lnterleukin-1 on the Function of Human Thyroid Cells.- Immunohistochemical Characterisation of Lymphocytes in Experimental Autoimmune Thyroiditis.- Lambda Light Chain Restriction in the Diffuse Thyroid Lymphoid infiltrate in Untreated Graves' Disease.- Natural Killer Cell Activity in Hashimoto, Graves' Disease and Euthyroid Exophthalmos.- Interaction of Purified Graves' Immunoglobulins with the TSH-receptor.- Thyroid Stimulating Immunoglobulins without Evidence of inVivo Thyroid Stimulation in Some Non-thyroid Autoimmune Disease.- The Effect of Thyroid Stimulating Immunoglobulins (TSI) on Thyroid cAMP: Comparison with TSH Activity.- Proliferation in Cultivated Follicles of Graves' Thyroids: Immunohistochemical Studies with Antibody KI-67.- The Significance of Immunoglobulins Related to Stimulation of Thyroid Growth in Patients with Endemic Goiter.- Regulation of Growth of Thyroid Cells in Culture by TSH Receptor Antibodies and Other Humoral Factors.- Polyamine Modulation of Responses to Graves' IgG in Guinea Pig and Human Thyroid.- Evidence for Intrathyroidal Production of Thyroid Growth-Stimulating Immunoglobulins.- Presence of Thyroid Growth Promoting Antibody in Patients with Graves' Disease in Remission: Medical versus Surgical Therapy.- Thyrotropin and Growth Promoting Immunoglobulin (TGI) of FRTL-5 Cells Have no Growth Stimulating Activity on Human Thyroid Epithelial Cell Cultures.- Autoantibodies Stimulating Thyroid Growth and Adenylate Cyclase Cannot Be Separated in IgGs from Graves' Disease.- Antiidiotypic Blocking of Graves' Disease Biologic Activity with Autologous Sera but not Consistently with Homologous Sera:Evidence for Polyclonality of Thyroid Receptor Antibodies (TRAb).- Autoantibodies Blocking the TSH-induced Adenylate Cyclase Stimulation in Idiopathic Myxedema and Hashimoto's Thyroiditis.- Relevance of Maternal Thyroid Autoantibodies on the Development of Congenital Hypothyroidism.- Ability of Immunoglobulins from Patients with Thyroid Disease to Stimulate Skin Fibroblasts.- Some Evidences that Thyrotropin and Autoantibodies Binding Sites are Locatea on Different Polypeptide Chains of * Thyroid Plasma Membrane Proteins.- Presence of Thyroid Growth Promoting Antibody in Patients with Hashimoto's Thyroiditis: Effect of Long-term Thyroxine Treatment.- Limited Clinical Value of TBI I and TSAb for Prediction of the Outcome of Patients with Graves' Disease.- TSH Receptor Antibodies in Neonatal Hyperthyroidism.- Thyroid Autoimmunity as a Major Cause for Congenital Hypothyroidism.- Thyroid Growth Blocking Antibodies in Congenital Hypothyroidism.- Incidence of TSH Receptor Antibodies in Patients with Toxic Diffuse Goiter.- Blocking Antibodies Apparently without Any Stimulatory Activity Are Present in Sera of Patients with Graves' Disease.- Increased Frequency of HLA-DR5 in Metro Toronto Patients with Goitrous Autoimmune Thyroiditis and Post-partum Thyroiditis.- Post-partum Thyroid Dysfunction and HLA Status.- Methimazole, gamma-Interferon and Graves' Disease.- The Prognostic Value of Combined Measurement of Thyroid-stimulating Antibody and Serum Thyroglobulin Levels during Graves' Disease Long Term Thionamide Treatment.- Serum Thyroid Autoantibodies in a Long-term Study of Thyrostatic Treatment of Graves1 Disease.- The Effect of High Doses of Carbimazole in Patients with Graves' Disease and in Subjects with Thyroid Antibodies.- Thymulin Deficiency and Low T3Syndrome in Infants with Low-Birth-weight Syndromes.- Constitutive Expression of HLA Class II Molecules in Human Thyroid Cells Transfected with SV-40.- Specific DNA Polymorphism in the DQ Alpha Region of Patients with Graves' Disease and Hashimoto's Thyroiditis.- Survey of Post-partum Thyroid Antimicrosomal Autoantibody as a Marker for Thyroid Dysfunction.- HLA Region Gene Involvement in Congenital Hypothyroidism.- Probability of a Beneficial, Dose-dependent, Immunosuppressive Action of Carbimazole in Graves' Disease.- Evidence for DR-Ag-expression by RHS-cells and not by Thyroid Epithelial Cells.- HLA-DR-ß Gene Analysis in Patients with Graves' Disease.- Immune Signals Fail to Elicit Endocrine Responses in the Obese Strain (OS) of Chickens with Hashimoto-like Autoimmune Thyroiditis.- Inappropriate HLA Class II Expression in a Wide Variety of Thyroid Diseases.- Adverse Reactions Related to Methimazole and Propylthiouracil Doses.- Thyroid Suppressibility in Graves' Disease: Relationship with Thyroid Stimulating Antibody and Serum Thyroalobulin Levels.- Influence of Lymphokines and Thyroid Hormones on Natural Killer Activity.- Results of Thyrostatic Drug Treatment in Hyperthyroidism. A Clinical Long-term Study.- Predictive Use of TSH-receptor Antibodies Assay as a Prognostic Index in Graves' Patients Treated with Antithyroid Drugs or Radioactive-Iodine.- Affinity Purification of Orbital Antigens Using Human Monoclonal Antibodies in Graves' Ophthalmopathy.- The Exophthalmos-related Eye Muscle Antigens Are not Related to Thyroid Antigens: Lack of Binding Inhibition Using Thyroid Microsomes and Thyroglobulin.- Humoral Immunity in Graves' Ophthalmopathy.- Autoantibodies of IgM and IgG Class against Eye Muscle Antigens in Patients wltfi GravesOphthalmopathy.- Endocrine Exophthalmos - Natural History and Results of Treatment.- Immunosuppressive Treatment of Graves' Ophthalmopathy with Cyclosporin A and Ciamexon.- Treatment of Graves' Ophthalmopathy by Retrobulbar Corticosteroids Associated with Orbital Cobalt Radiotherapy.- Immunological Features of Simple Endemic Goitre.- Thyroid Autoimmunity in Five Samples of General Population in Italy.- Prevalence of Hypothyroidism and Hashimoto's Thyroiditis in Two Elderly Populations at Different Dietary Iodine Intake.- Evidence of the Influence of Iodine Intake on the Prevalence of Autoimmune Factors in Hyperthyroid Patients Living in an Endemic Goitre Area.- Further Data on Iodine-induced Autoimmunity.- Study of Class I and Class II Antigen Expression and Lymphocytic Infiltrate on Thyroid Tumors.- Incidence of Anti-thyroid Autoantibodies in Thyroid Cancer Patients.- Thyroid Autoantibodies in Thyroid Cancer.- Some Aspects of Cell Mediated Autoimmunity in Endemic Nodular Goitre.- Chronic Lymphocytic Thyroiditis in Endemic Goiter: Local Ig Production and Deposition.- Autoimmune Thyroid Disease in the City of Graves.- A Retrospective Study of Thyroid Autoimmunity and Hypothyroidism in a Random Obese Population.- Circulating Thyroid Autoantibodies in Children and Youngsters with Insulin Dependent Diabetes Mellitus (IDDM) Are not Predictive of Overt Autoimmune Thyroid Disease.- Effects of Chronic Amiodarone Administration on Humoral Thyroid Autoimmunity.- Serum Thyroid Autoantibodies in Patients with Breast Cancer.- Complement Activities and Circulating Immune Complexes in Sera of Patients with Graves' Disease and Hashimoto's Thyroiditis.- Abnormalities of Thyroid Function in Sjogren's Syndrome.- 6, Lombardi, F.S. AmbesHmpiombato and G, Marone Thyroid andRenal Amyloidosis in Thyroglobulin Immunized Rabbits.- Absence of Thyroglobulin in Kidney of Patients with Autoimmune Thyroiditis and Nephropathies.- Persistence of Autoimmune Reactions During Recovering of Subacute Thyroiditis.- Purified Protein Derivative Reaction and Urinary Immunosuppressive Acidic Protein in Patients with Subacute Thyroiditis.- Interferences of Circulating Anti-TSH Antibodies in Methods for Thyrotropin Measurement.