Toxicoepigenetics (eBook, ePUB)

Core Principles and Applications
Redaktion: Mccullough, Shaun D.; Dolinoy, Dana

• Format: ePub

Produktbeschreibung

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study.

• Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology
• Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds
• Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 428
• Erscheinungstermin: 2. November 2018
• Englisch
• ISBN-13: 9780128124345
• Artikelnr.: 54496940

Inhaltsangabe

1. The Role of Histone Acetylation and Acetyltransferases in Gene
Regulation 2. The Role of Histone Methylation and Methyltransferases in
Gene Regulation 3. Linking Chromatin Accessibility with Exposure Effects
and Susceptibility 4. Implications for Chromatin Biology in Toxicology 5.
The Role of DNA Methylation in Gene Regulation 6. Implications of DNA
Methylation in Toxicology 7. DNA Methylation as a Biomarker in
Environmental Epidemiology 8. DNA Hydroxymethylation: Implications for
Toxicology and Epigenetic Epidemiology 9. The Role of Non-Coding RNAs in
Gene Regulation 10. miRNAs and lncRNAs as Biomarkers of Toxicant Exposure
11. Germline and Trans-generational Impacts of Toxicant Exposures 12. Novel
Bioinformatics Methods for Toxicoepigenetics 13. Incorporating Epigenetics
into Risk Assessment Frameworks 14. Chromatin Immunoprecipitation: General
Protocol and Considerations for Analysis 15. Methods for Analysis of DNA
Methylation 16. Methods for Analyzing miRNA Expression