Saura C. Sahu

Toxicogenomics (eBook, PDF)

A Powerful Tool for Toxicity Assessment

• Format: PDF

Produktbeschreibung

Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: * mechanistic toxicogenomics * analysis and interpretation of toxicogenomic data * principles of data mining in toxicogenomics * design issues in toxicogenomics studies * sources of variability in toxicogenomic assays * Escherichia coli stress response as a tool for detection of toxicity * toxicogenomics as a tool to assess immunotoxicity * toxicogenomics and ecogenomics for studying endocrine disruption and basic biology * use of toxicogenomics as an early predictive tool for hepatotoxicity * nutrigenomics: the application of genomic signatures in nutrition-related research * application of toxicogenomics in drug discovery * potential uses of toxicogenomic biomarkers in occupational health and risk assessment * usefulness of toxicogenomics in the regulatory environment * perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.

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Produktdetails

• Verlag: Wiley-Blackwell
• Seitenzahl: 422
• Erscheinungstermin: 20. November 2008
• Englisch
• ISBN-13: 9780470699645
• Artikelnr.: 37753878

Autorenporträt

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, Dec 2007).

Inhaltsangabe

1. Mechanistic toxicogenomics: Design and analysis of microarray
experiments (Kirstin Meyer, Susanne Schwenke and Johanna M. Beekman).
2. Analysis and interpretation of toxicogenomic data: Biological responses
to low, environmentally-relevant doses of toxicants (Julia A. Gosse,
Jennifer Davey, Thomas Hampton and Joshua Hamilton).
3. Principles of data-mining in toxicogenomics (Yoko Hirabayashi and Tohru
Inoue).
4. Design issues in toxicogenomics studies: The application of genomic
technologies for mechanistic and predictive research (Woong-Yang Park, Lian
Li and Daehee Kang).
5. Sources of variability in toxicogenomic assays (Karol Thompson, P. Scott
Pine and Barry Rosenzweig).
6. Key aspects of toxicogenomic data analysis and interpretation as a
safety assessment tool to identify and understand drug-induced toxicity
(Antoaneta Vladimirova and Brigitte Ganter).
7. Toxicogenomics as a tool to assess immunotoxicity (Kirsten Baken, J.
Ezendam, J. Pennings, R. Vandebriel,and H. Loveren).
8. Toxicogenomics and ecogenomics for studying endocrine disruption and
basic biology (Taisen Iguchi, Hajime Watanabe and Yoshino Kata).
9. Gene expression profiling of transplacental arsenic carcinogenesis in
mice (Jie Liu, B. Diwan, R. Tennant and Michael Waalkes).
10. Characterization of estrogen active compounds and estrogenic signaling
by global gene expression profiling in vitro (Stephanie Simon, Kathleen
Boehme, Susanne Schmidt and Stephan Mueller).
11. Escherichia coli stress response as a tool for detection of toxicity
(Arindam Mitra, Nabarun Chakraborti and Suman Mukhopadhyay).
12. Toxicogenomics in vitro: A powerful tool for screening hepatotoxic
potential of food-related products (Saura C. Sahu).
13. Toxicogenomics approach to drug-induced phospholipidosis (Hiroshi
Sawada).
14. Use of toxicogenomics as an early predictive tool for Hepatotoxicity
(Laura Suter).
15. Nutrigenomics: The application of genomic signatures in
nutrition-related research (Stamotis Theocharis and Elisavet Gatzidou).
16. Application of toxicogenomics in drug discovery (Michael Liguori, Amy
Ditewig and Jeffery Waring).
17. Natural products from medicinal plants and risk assessment (Leila
Chekir-Ghedira).
18. The development of a metabonomic-based drug safety testing paradigm
(Muireann Coen, Elaine Holms, Jeremy Nicholson and John Lindon).
19. Potential Uses of Toxicogenomic Biomarkers in Occupational Health and
Risk Assessment (Paul A. Nony).
20. Usefulness of toxicogenomics in the regulatory environment (Daniel
Casciano).
21. Toxicogenomics for regulatory use: the view from the bench (P. Ancian,
S.Leuillett, S. Artaud, J. Jegard and Roy Forster).
22. Perspectives on toxicogenomics at the US Environmental Protection
Agency (Karen Hamernik, Kenneth Haymes, Susan Hester and Thomas
McClintock).

Rezensionen

"For those wishing to gain an insight the potential power of toxicogenomics in toxicity assessment Toxicogenomics: A Powerful Tool for Toxicity Assessment will be if interest." ( BTS Newsletter , Summer 2009)