Transcription and Translation in Health and Disease (eBook, ePUB)

Redaktion: Garg, Manoj; Pandey, Amit Kumar; Sethi, Gautam

• Format: ePub

Produktbeschreibung

Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications.

It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention.

• Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease
• Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins
• Covers the topic from fundamental knowledge to the latest developments in clinical application
• Includes a section dedicated to therapeutic applications

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 416
• Erscheinungstermin: 30. Januar 2023
• Englisch
• ISBN-13: 9780323995221
• Artikelnr.: 67376930

Inhaltsangabe

Section I: Introduction 1. Current perspectives on transcription and
translational regulators in Health and diseases 2. Role of alternative
splicing in health and diseases
Section II: Transcriptional and translational regulators in cancer 3.
Transcriptional regulation in cancer progression 4. Role of transcriptional
and post-transcriptional regulation of sphingolipid genes in molecular
heterogeneity of breast cancer 5. Who dictates and when: Genetic and
epigenetic dictatorships in breast cancer response and resistance to
therapy 6. CRISPR/Cas9 mediated regulation in cancer 7. Biomarkers for
Diagnosis, Prognosis, Treatment of Gastro-Intestinal cancer 8. Regulation
of post-transcriptional events by RNA-binding proteins 9. The language of
post-translational modifications in cancers and other diseases 10.
Ubiquitin proteasome system-mediated regulation of protein function and
stability 11. Post-transcriptional regulations in epithelial-tomesenchymal
transition and endothelial-to-mesenchymal transitions
Section III: Transcriptional and translation regulators of other diseases
12. Noncoding RNAs in Diabetes 13. MicroRNAs as epigenetic regulators for
gut microbiome 14. Cross talk between miRNAs and epigenetics during
braindevelopment and neurological diseases 15. The role of non-coding RNAs
in rheumatoid arthritis 16. Role of miRNA in autoimmune and inflammatory
skin diseases 17. Current Advances in Cancer Prevention and Treatment by
Natural Products 18. Therapeutic inhibition of pro-inflammatory cytokins by
phytochemicals in osteoarthritis 19. Redox Signaling and Cardiovascular
Disease: New Paradigms and discoveries
Section IV: Therapeutics 20. Modulation of epigenetic enzymes by natural
agents 21. Inhibitors targeting epigenetic modifications in cancer 22. Drug
rechanneling a new paradigm for cancer treatment