Transition States of Biochemical Processes (eBook, PDF)

Redaktion: Gandour, R.

• Format: PDF

Produktbeschreibung

The transItIOn-state theory has been, from the point of its inception, the most influential principle in the development of our knowledge of reaction mechanisms in solution. It is natural that as the field of biochemical dynamics has achieved new levels of refinement its students have increasingly adopted the concepts and methods of transition-state theory. Indeed, every dynamical problem of biochemistry finds its most elegant and economical statement in the terms of this theory. Enzyme catalytic power, for example, derives from the interaction of enzyme and substrate structures in the transition state, so that an understanding of this power must grow from a knowledge of these structures and interactions. Similarly, transition-state interactions, and the way in which they change as protein structure is altered, constitute the pivotal feature upon which molecular evolution must turn. The complete, coupled dynamical system of the organism, incorporating the transport of matter and energy as well as local chemical processes, will eventually have to yield to a description of its component transition-state structures and their energetic response characteristics, even if the form of the description goes beyond present-day transition-state theory. Finally, the importance of biochemical effectors in medicine and agriculture carries the subject into the world of practical affairs, in the use of transition-state information for the construction of ultra potent biological agents.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 616
• Erscheinungstermin: 29. Juni 2013
• Englisch
• ISBN-13: 9781468499780
• Artikelnr.: 43994499

Inhaltsangabe

1 - Scope and Limitations of the Concept of the Transition State.- 2 - Catalytic Power and Transition-State Stabilization.- 3 - Quantum-Mechanical Approaches to the Study of Enzymic Transition States and Reaction Paths.- 4 - Primary Hydrogen Isotope Effects.- 5 - Secondary Hydrogen Isotope Effects.- 6 - Solvent Hydrogen Isotope Effects.- 7 - Heavy-Atom Isotope Effects in Enzyme-Catalyzed Reactions.- 8 - Magnetic-Resonance Approaches to Transition-State Structure.- 9 - Mapping Reaction Pathways from Crystallographic Data.- 10 - Transition-State Properties in Acyl and Methyl Transfer.- 11 - Transition States for Hydrolysis of Acetals, Ketals, Glycosides, and Glycosylamines.- 12 - Decarboxylations of ?-Keto Acids and Related Compounds.- 13 - The Mechanism of Phosphoryl Transfer.- 14 - Intramolecular Reactions and the Relevance of Models.- 15 - Transition-State Affinity as a Basis for the Design of Enzyme Inhibitors.- 16 - Transition-State Theory and Reaction Mechanism in Drug Action and Drug Design.- Author Index.