Translational Models of Parkinson's Disease and related Movement Disorders (eBook, ePUB)

Redaktion: Mohamed MD

• Format: ePub

Produktbeschreibung

Translational Models of Parkinson's Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson's Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book also highlights the future possibilities of introducing new models for Parkinson's Disease and related movements disorders, underscoring current advancements, pre-clinical and clinical developments, and future scope related to numerous models. - Highlights induction and validation of different available experimental models of Parkinson's Disease - Provides a comparative prospect of different experimental models of Parkinson's Disease - Discusses the advantages and disadvantages of each model, including associated limitations

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 480
• Erscheinungstermin: 27. November 2024
• Englisch
• ISBN-13: 9780443161292
• Artikelnr.: 72244288

Inhaltsangabe

Section I. Understanding PD and related movement disorders 1.
Neuroinflammation, glymphatic system, and Parkinson's disease 2.
Pharmacotherapy of PD and related movements disorders and their limitations
3. Diagnosis and biomarkers of Parkinson's disease and related movement
disorders 4. OMICS and bioinformatics in Parkinson disease and related
movements disorders 5. Modeling Parkinson's disease with the
alpha-synuclein protein 6. ¿-Synuclein seeding assay and analysis Section
II. Mammalian models of Parkinson's disease 7. SHH, nurr1, pitx3, and en1
models for Parkinson's disease 8. Stem cell for PD: Technical
considerations 9. Deep brain stimulation using animal models of Parkinson's
disease 10. The MitoPark mouse model of Parkinson's disease 11. The
beta-sitosterol beta-D-glucoside (BSSG) rat model of Parkinson's disease
Section III. Invertebrate models of Parkinson's disease 12. SCA1 zebrafish
model 13. Various zebrafish models of Parkinson's disease: What gives us
hope 14. Drosophila PD model 15. Caenorhabditis elegans models of tauopathy
16. LRRK2 in Caenorhabditis elegans model Section IV. Ethics and
regulations related to translational PD models 17. Confounding factors for
validation of PD models 18. Neurobehavioral characterization of PD models
19. Ethical regulations for induction and validation of PD models 20. The
OMICS and PD models: Hopes or hypes 21. Parkinson's disease from an
Ayurveda perspective: Opportunities and challenges for further research