Translational Systems Medicine and Oral Disease (eBook, ePUB)

Redaktion: Sonis DMD, DMSc; Villa DDS

• Format: ePub

Produktbeschreibung

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others.

In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care.

• Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine
• Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases
• Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader
• Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 458
• Erscheinungstermin: 14. September 2019
• Englisch
• ISBN-13: 9780128137635
• Artikelnr.: 61688977

Autorenporträt

Dr. Sonis is senior academic at Harvard, Brigham and Women's Hospital and the Dana-Farber Cancer Institute and a world-renowned expert in epithelial injury associated with cancer therapy. His development of predictive animal models has enabled the investigation of the biological basis of cancer regimen-related epithelial injury and has catalyzed the development of potential therapies. Dr. Sonis' interest in the genomic basis for toxicity risk and its pathology has led to innovative genomics-based analytical approaches to clinically actionable outcomes to personalize disease therapy. He has published extensively on the clinical, biological, and health economic aspects of cancer and complications associated with its treatment. Steve holds several patents and is the author of more than 275 original publications, reviews, and chapters and is completing his eleventh book. He obtained degrees from Tufts and Harvard and completed his post-doctoral education (tumor immunology) at Oxfo

rd University where he was a Knox Fellow.

Inhaltsangabe

1. Introduction to systems medicine 2. Genomics 3. Proteomics 4. Metabolomics 5. Microbiomics 6. Functional "Omics for systems medicine 7. Analytic methods for systems medicine 8. Epigenetics and oral diseases 9. Systems medicine in periodontal disease 10. Oral and systemic health 11. Systems medicine in the diseases of the bone 12. Systems medicine and salivary gland diseases 13. Systems medicine and neuropathic oral diseases 14. Systems medicine in oral oncology 15. Systems medicine and autoimmune diseases 16. Stem cells and regenerative medicine 17. Practical considerations applications 18. Conclusion and future directions