Tumor Suppressor Genes (eBook, PDF)

Volume 1: Pathways and Isolation Strategies
Redaktion: El-Deiry, Wafik S.

• Format: PDF

Produktbeschreibung

Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to isolate and characterize novel tumor suppressor genes and their targets. The companion volume of this set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, demonstrates how best to explore the cell biology and biochemical function of such genes, and their encoded proteins, to study their physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer. Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 520
• Erscheinungstermin: 3. Februar 2008
• Englisch
• ISBN-13: 9781592593286
• Artikelnr.: 64700454

Autorenporträt

Wafik S. El-Deiry, M.D., Ph.D, is Professor of Medicine, Chief, Hematology/Oncology, Rose Dunlap Division Chair in Hematology/Oncology, and Associate Director for Translational Researchat Penn State Hershey Cancer Institute. Dr. El-Deiry is a well-respected and notable figure among cancer researchers, scientists, and clinicians. He has published almost 300 papers in his career and has over 29,000 totol citations, with an excellent h-index of 70.

Inhaltsangabe

Known Tumor Suppessor Genes and Pathways.- Growth Control by the Retinoblastoma Gene Family.- The APC Tumor Suppressor Pathway.- Hereditary Breast and Ovarian Cancer Genes.- Hereditary Colon Cancer Genes.- Patched, Hedgehog, and Skin Cancer.- Tumor Suppressor Genes in Lung Cancer.- TP53, hChk2, and the Li-Fraumeni Syndrome.- Genetic Alterations in Esophageal Cancer.- PTEN and Cancer.- VHL and Kidney Cancer.- p16INK4A and Familial Melanoma.- The INK4a/ARF Locus and Human Cancer.- Progression Model of Prostate Cancer.- Neurofibromatosis Type 1.- Wilms' Tumor as a Model for Cancer Biology.- Inadequate "Caretaker" Gene Function and Human Cancer Development.- The Regulation of Tumor Suppressor Genes by Oncogenes.- Identification of Tumor Suppressor Genes.- Determination of Cancer Allelotype.- Epidemiological Approaches to the Identification of Cancer Predisposition Genes.- Characterization of Translocations in Human Cancer.- Positional Approaches to Cancer Genetics.- Hybrid Capture of Putative Tumor Suppressor Genes.- Approaches to Proteomic Analysis of Human Tumors.- Representational Difference Analysis of Gene Expression.- Antisense Libraries to Isolate Tumor Suppressor Genes.- Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes.- Cross-linking Subtractive Hybridization to Identify Tumor Suppressor Genes.- Suppression Subtractive Hybridization for Identification and Functional Analysis of Tumor Suppressor Genes.- SAGE as a Strategy to Isolate Cancer-Related Genes.- Differential Display Techniques to Identify Tumor Suppressor Gene Pathways.- Detection of Mismatch Repair Gene Expression in Urologic Malignancies.