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In this remarkable volume, Dr. Jay A. Goldstein clearly presents both the theoretical and the practical aspects of this revolutionary approach to treating CFS and other conditions that have often been termed psychosomatic. Dr. Goldstein will show you how he achieves results for patients with CFS and a variety of other syndromes in days, rather than months or years. From the most basic questionsWhat is neurosomatic medicine? and How can treatments sometimes work so rapidly?to specific technical concernsWhat is receptor profiling, and how does it indicate the type of receptor dysregulation in an…mehr
In this remarkable volume, Dr. Jay A. Goldstein clearly presents both the theoretical and the practical aspects of this revolutionary approach to treating CFS and other conditions that have often been termed psychosomatic. Dr. Goldstein will show you how he achieves results for patients with CFS and a variety of other syndromes in days, rather than months or years. From the most basic questionsWhat is neurosomatic medicine? and How can treatments sometimes work so rapidly?to specific technical concernsWhat is receptor profiling, and how does it indicate the type of receptor dysregulation in an individual patient?Tuning the Brain: Principles and Practice of Neurosomatic Medicine provides the answers in a clear and cogent manner. You'll learn which abnormalities in brain function produce neurosomatic disorders and how an understanding of these abnormalities can help you provide effective treatment.
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Autorenporträt
Jay Goldstein
Inhaltsangabe
* Foreword * Preface * Abbreviations * Part I: Inventing Neurosomatic Medicine: Rewards and Satisfactions versus Problems and Pitfalls * Chapter 1. The Education of a Neurosomaticist * Chapter 2. The Office Practice of Neurosomatic Medicine * Bankruptcy Despite a Three-Month Waiting List * Solving the Problems and Avoiding the Pitfalls * Taking Care of Business * Chapter 3. Lawyers and Litigation * Sample Pathophysiology of Posttraumatic Fibromyalgia * Mene, Mene, Tekel, Upharsin * Chapter 4. Treatment Case Examples * Instantaneous Neural Network Reconfiguration by Pharmacologic Modulation of Afferent Cranial Nerve Input * The Pathophysiology of CFS and Related Neurosomatic Disorders * Thyroid Function in Neurosomatic Disorders: Stimulation of Trigeminal Nerve Activity with Thyrotropin-Releasing Hormone (TRH) * Chapter 5. Case Reports * My So-Called Illness: Is It Real or All in My Head? * One-Second Epiphanies * My Most Unusual Case * Bug-of-the-Month Club * Chapter 6. Married to a Doctor Who Is Married to His Practice * Part II: Society for Neuroscience Conference Proceedings * Chapter 7. This Is . . . Los Angeles * Chapter 8. Neurosomatic Pearls * Eldritch Lore About Neurosomatic Therapy * Chapter 9. Neurosomatic Neuroscience * Part III: Pathophysiology and Treatment * Chapter 10. Treatment of Neurosomatic Disorders * Abecarnil and Acamprosate * Stimulants * The Corticostriatal-Thalamocortical (CSTC) Circuit in Reverse * Corticotropin-Releasing Hormone (CRH) and Hypocortisolism * Agmatine * Cholinesterase Inhibitors * Ascorbate (Vitamin C) * Amantadine * Adenosine * Baclofen * Gamma-Aminobutyric Acid (GABA) * Adenosine Triphosphate (ATP) * Lorazepam Nasal Spray * Antibiotics * Endothelin (ET) * Respiratory Rhythm Regulation in Fibromyalgia Syndrome * pH and Panic Disorder * Buspirone/BuSpar * Thalamic Reticular Nucleus * The Attentional Network * Clonidine * Catecholamines * Norepinephrine, Dopamine, Salience, and Attention * Dopamine and Reward * Effexor (Venlafaxine) * Synaptic Plasticity and Long-Term Potentiation in Neurosomatic Disorders * The Postreceptor Phosphorylation Cascade * The Treatment of Attentional Disorders * Instantaneous Neural Network Reconfiguration * Other Aspects of Synaptic Plasticity * Hormonal Modulation in Neurosomatic Medicine * Modulating the N-Methyl-D-Aspartate (NMDA) Receptor * Atypical Messengers * Synaptic Fatigue * Glutamate Receptors, Subunits, and Synaptic Scaling * Neurotrophic Factors * Metabotropic Glutamate Receptors * Conclusion * Chapter 11. Modulating Glutamatergic Neurotransmission * Ketamine * Pharmacologic Modulation of Sensory Integration via the Trigeminal Nerve * Electroconvulsive Therapy (ECT) * Kinases and Phosphatases * The Nicotinic Cholinergic Receptor * Long-Term Potentiation and Depression * Mitogen-Activated Protein Kinases (MAPKs) * Gabapentin * Zolpidem * Lamotrigine * Pentazocine (Talwin) * Oxytocin * Opioids * Oxytocin, Hypothalamic Function, and Circadian Rhythms * Other Effects of Oxytocin * Modafinil (Provigil) * Ventrolateral Preoptic Nucleus (VLPO) * Lidocaine * Gonadotropin-Releasing Hormone (GnRH) and Dysregulation of Circadian Rhythms * Pyrrolidines * Fatigue * Sleep * Conclusion * Conclusion. Closing the Circuit: The Role of the Nucleus Accumbens in Neurosomatic Disorders * Appendix * Diagnostic Criteria from the DSM-IV-TR * Treatment Algorithm * Medication List: Present and Near-Future Treatment Options for Neurosomatic Disorders * CFS Symptom Checklist * References * Index
Foreword
Preface
Abbreviations
Part I: Inventing Neurosomatic Medicine: Rewards and Satisfactions versus Problems and Pitfalls
Chapter 1. The Education of a Neurosomaticist
Chapter 2. The Office Practice of Neurosomatic Medicine
Bankruptcy Despite a Three-Month Waiting List
Solving the Problems and Avoiding the Pitfalls
Taking Care of Business
Chapter 3. Lawyers and Litigation
Sample Pathophysiology of Posttraumatic Fibromyalgia
Mene, Mene, Tekel, Upharsin
Chapter 4. Treatment Case Examples
Instantaneous Neural Network Reconfiguration by Pharmacologic Modulation of Afferent Cranial Nerve Input
The Pathophysiology of CFS and Related Neurosomatic Disorders
Thyroid Function in Neurosomatic Disorders: Stimulation of Trigeminal Nerve Activity with Thyrotropin-Releasing Hormone (TRH)
Chapter 5. Case Reports
My So-Called Illness: Is It Real or All in My Head?
One-Second Epiphanies
My Most Unusual Case
Bug-of-the-Month Club
Chapter 6. Married to a Doctor Who Is Married to His Practice
Part II: Society for Neuroscience Conference Proceedings
Chapter 7. This Is . . . Los Angeles
Chapter 8. Neurosomatic Pearls
Eldritch Lore About Neurosomatic Therapy
Chapter 9. Neurosomatic Neuroscience
Part III: Pathophysiology and Treatment
Chapter 10. Treatment of Neurosomatic Disorders
Abecarnil and Acamprosate
Stimulants
The Corticostriatal-Thalamocortical (CSTC) Circuit in Reverse
Corticotropin-Releasing Hormone (CRH) and Hypocortisolism
Agmatine
Cholinesterase Inhibitors
Ascorbate (Vitamin C)
Amantadine
Adenosine
Baclofen
Gamma-Aminobutyric Acid (GABA)
Adenosine Triphosphate (ATP)
Lorazepam Nasal Spray
Antibiotics
Endothelin (ET)
Respiratory Rhythm Regulation in Fibromyalgia Syndrome
pH and Panic Disorder
Buspirone/BuSpar
Thalamic Reticular Nucleus
The Attentional Network
Clonidine
Catecholamines
Norepinephrine, Dopamine, Salience, and Attention
Dopamine and Reward
Effexor (Venlafaxine)
Synaptic Plasticity and Long-Term Potentiation in Neurosomatic Disorders
The Postreceptor Phosphorylation Cascade
The Treatment of Attentional Disorders
Instantaneous Neural Network Reconfiguration
Other Aspects of Synaptic Plasticity
Hormonal Modulation in Neurosomatic Medicine
Modulating the N-Methyl-D-Aspartate (NMDA) Receptor
Atypical Messengers
Synaptic Fatigue
Glutamate Receptors, Subunits, and Synaptic Scaling
* Foreword * Preface * Abbreviations * Part I: Inventing Neurosomatic Medicine: Rewards and Satisfactions versus Problems and Pitfalls * Chapter 1. The Education of a Neurosomaticist * Chapter 2. The Office Practice of Neurosomatic Medicine * Bankruptcy Despite a Three-Month Waiting List * Solving the Problems and Avoiding the Pitfalls * Taking Care of Business * Chapter 3. Lawyers and Litigation * Sample Pathophysiology of Posttraumatic Fibromyalgia * Mene, Mene, Tekel, Upharsin * Chapter 4. Treatment Case Examples * Instantaneous Neural Network Reconfiguration by Pharmacologic Modulation of Afferent Cranial Nerve Input * The Pathophysiology of CFS and Related Neurosomatic Disorders * Thyroid Function in Neurosomatic Disorders: Stimulation of Trigeminal Nerve Activity with Thyrotropin-Releasing Hormone (TRH) * Chapter 5. Case Reports * My So-Called Illness: Is It Real or All in My Head? * One-Second Epiphanies * My Most Unusual Case * Bug-of-the-Month Club * Chapter 6. Married to a Doctor Who Is Married to His Practice * Part II: Society for Neuroscience Conference Proceedings * Chapter 7. This Is . . . Los Angeles * Chapter 8. Neurosomatic Pearls * Eldritch Lore About Neurosomatic Therapy * Chapter 9. Neurosomatic Neuroscience * Part III: Pathophysiology and Treatment * Chapter 10. Treatment of Neurosomatic Disorders * Abecarnil and Acamprosate * Stimulants * The Corticostriatal-Thalamocortical (CSTC) Circuit in Reverse * Corticotropin-Releasing Hormone (CRH) and Hypocortisolism * Agmatine * Cholinesterase Inhibitors * Ascorbate (Vitamin C) * Amantadine * Adenosine * Baclofen * Gamma-Aminobutyric Acid (GABA) * Adenosine Triphosphate (ATP) * Lorazepam Nasal Spray * Antibiotics * Endothelin (ET) * Respiratory Rhythm Regulation in Fibromyalgia Syndrome * pH and Panic Disorder * Buspirone/BuSpar * Thalamic Reticular Nucleus * The Attentional Network * Clonidine * Catecholamines * Norepinephrine, Dopamine, Salience, and Attention * Dopamine and Reward * Effexor (Venlafaxine) * Synaptic Plasticity and Long-Term Potentiation in Neurosomatic Disorders * The Postreceptor Phosphorylation Cascade * The Treatment of Attentional Disorders * Instantaneous Neural Network Reconfiguration * Other Aspects of Synaptic Plasticity * Hormonal Modulation in Neurosomatic Medicine * Modulating the N-Methyl-D-Aspartate (NMDA) Receptor * Atypical Messengers * Synaptic Fatigue * Glutamate Receptors, Subunits, and Synaptic Scaling * Neurotrophic Factors * Metabotropic Glutamate Receptors * Conclusion * Chapter 11. Modulating Glutamatergic Neurotransmission * Ketamine * Pharmacologic Modulation of Sensory Integration via the Trigeminal Nerve * Electroconvulsive Therapy (ECT) * Kinases and Phosphatases * The Nicotinic Cholinergic Receptor * Long-Term Potentiation and Depression * Mitogen-Activated Protein Kinases (MAPKs) * Gabapentin * Zolpidem * Lamotrigine * Pentazocine (Talwin) * Oxytocin * Opioids * Oxytocin, Hypothalamic Function, and Circadian Rhythms * Other Effects of Oxytocin * Modafinil (Provigil) * Ventrolateral Preoptic Nucleus (VLPO) * Lidocaine * Gonadotropin-Releasing Hormone (GnRH) and Dysregulation of Circadian Rhythms * Pyrrolidines * Fatigue * Sleep * Conclusion * Conclusion. Closing the Circuit: The Role of the Nucleus Accumbens in Neurosomatic Disorders * Appendix * Diagnostic Criteria from the DSM-IV-TR * Treatment Algorithm * Medication List: Present and Near-Future Treatment Options for Neurosomatic Disorders * CFS Symptom Checklist * References * Index
Foreword
Preface
Abbreviations
Part I: Inventing Neurosomatic Medicine: Rewards and Satisfactions versus Problems and Pitfalls
Chapter 1. The Education of a Neurosomaticist
Chapter 2. The Office Practice of Neurosomatic Medicine
Bankruptcy Despite a Three-Month Waiting List
Solving the Problems and Avoiding the Pitfalls
Taking Care of Business
Chapter 3. Lawyers and Litigation
Sample Pathophysiology of Posttraumatic Fibromyalgia
Mene, Mene, Tekel, Upharsin
Chapter 4. Treatment Case Examples
Instantaneous Neural Network Reconfiguration by Pharmacologic Modulation of Afferent Cranial Nerve Input
The Pathophysiology of CFS and Related Neurosomatic Disorders
Thyroid Function in Neurosomatic Disorders: Stimulation of Trigeminal Nerve Activity with Thyrotropin-Releasing Hormone (TRH)
Chapter 5. Case Reports
My So-Called Illness: Is It Real or All in My Head?
One-Second Epiphanies
My Most Unusual Case
Bug-of-the-Month Club
Chapter 6. Married to a Doctor Who Is Married to His Practice
Part II: Society for Neuroscience Conference Proceedings
Chapter 7. This Is . . . Los Angeles
Chapter 8. Neurosomatic Pearls
Eldritch Lore About Neurosomatic Therapy
Chapter 9. Neurosomatic Neuroscience
Part III: Pathophysiology and Treatment
Chapter 10. Treatment of Neurosomatic Disorders
Abecarnil and Acamprosate
Stimulants
The Corticostriatal-Thalamocortical (CSTC) Circuit in Reverse
Corticotropin-Releasing Hormone (CRH) and Hypocortisolism
Agmatine
Cholinesterase Inhibitors
Ascorbate (Vitamin C)
Amantadine
Adenosine
Baclofen
Gamma-Aminobutyric Acid (GABA)
Adenosine Triphosphate (ATP)
Lorazepam Nasal Spray
Antibiotics
Endothelin (ET)
Respiratory Rhythm Regulation in Fibromyalgia Syndrome
pH and Panic Disorder
Buspirone/BuSpar
Thalamic Reticular Nucleus
The Attentional Network
Clonidine
Catecholamines
Norepinephrine, Dopamine, Salience, and Attention
Dopamine and Reward
Effexor (Venlafaxine)
Synaptic Plasticity and Long-Term Potentiation in Neurosomatic Disorders
The Postreceptor Phosphorylation Cascade
The Treatment of Attentional Disorders
Instantaneous Neural Network Reconfiguration
Other Aspects of Synaptic Plasticity
Hormonal Modulation in Neurosomatic Medicine
Modulating the N-Methyl-D-Aspartate (NMDA) Receptor
Atypical Messengers
Synaptic Fatigue
Glutamate Receptors, Subunits, and Synaptic Scaling
