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Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of COVID-19 aims to cover all aspects of COVID-19 infection from the virus, transmission, pathogenesis, immune-inflammation response, systemic injury, organ damage and associated factors comorbidities that drive mortality. Treatment protocols and the vaccination paradigm will also be discussed. Organized into ten sections, the book aims to provide a comprehensive examination of the impact of COVID-19. The book begins a review of coronaviruses, their structure and mechanism of action. The book goes on to discuss the immune…mehr
Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of COVID-19 aims to cover all aspects of COVID-19 infection from the virus, transmission, pathogenesis, immune-inflammation response, systemic injury, organ damage and associated factors comorbidities that drive mortality. Treatment protocols and the vaccination paradigm will also be discussed. Organized into ten sections, the book aims to provide a comprehensive examination of the impact of COVID-19. The book begins a review of coronaviruses, their structure and mechanism of action. The book goes on to discuss the immune response to the virus and its effect on various organs. It examines clinical cases based on an observations and postmortem studies. Other topics include the long-term effects of COVD-19, vaccines, and public health response. . Discusses coronavirus, their similarities and differences in origin and transmission as well as a review of their structure and mechanisms of action. Examines the immune-inflammation responses to COVID-19 and the organ-specific impact of the disease. Covers vaccines and other treatment protocols and public health responses in various geographic locations
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Inhaltsangabe
Section 1: Coronaviruses (including SARS 1 and MERS), the Structure (sequence), Mechanism of Action Introduction 1. Origin, Evolution and Spread of SARS CoV 2 2. SARS CoV 2 Spike Proteins in Infectivity 3. Structural and functional properties of the SARS CoV 2 spike protein: potential vaccine and drug development for COVID 19 4. Population Specific Polymorphisms and SARS CoV 2 Infectivity 5. Insights into SARS CoV 2 Structure: Approaches and Action of SARS CoV 2 Main Protease Inhibitors 6. SARS CoV 2, SARS CoV, and MERS COV: Similarities and Differences in Origin and Transmission Section 2: Inflammation and Immune Response to SARS CoV 2 Introduction 7. Characterization of the Immune Response with Viral Attack 8. Inflammation, Cytokines and COVID 19 Severity 9. Immunological Considerations for COVID 19: Vaccines and Other Protective Strategies 10. Virus specific T cell response in SARS CoV 2 infection and vaccinations 11. Oral and Gut Inflammation and Microbiota with COVID 19 12. Implications of Inflammation: Bone and Joint Health with COVID 19 13. COVID 19 and immune dysfunction: Consequences, and natural remedies for management Section 3: Pathological Findings with Clinical Correlation Introduction 14. Pulmonary Pathology of Severe Covid 19 15. Histopathological Analysis of the Cardiovascular System in severe COVID 19 16. Postmortem Neuropathology in COVID 19 17. Renal Pathology in Severe Covid 19 Section 4: The Blood Vessels and COVID 19: Vascular Dysfunction and Coagulopathies Introduction 18. Vascular Manifestations of COVID 19: Endothelial Dysfunction and Damage 19. Immunothrombosis involvement in COVID 19 20. COVID 19 associated coagulopathy 21. D dimer in systemic circulation and COVID 19 outcome 22. Hypercoagulability in COVID 19 Section 5: Neuro COVID 19 and its Long Term Implications Introduction 23. COVID and the Nervous System: Mechanisms and Consequences 24. Neuroinflammation: Unraveling Acute and Long COVID 19 Effects 25. Acute and Post acute Neurologic and Psychiatric Manifestations in COVID 19 26. Pediatric Neurological and Neuropsychiatric Manifestations of COVID 19 27. Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of Covid 19 Section 6: Should Covid 19 Concern Nephrologists? Why and to What Extent?" Introduction 28. Acute Kidney Injury with COvid 19: Mechanisms, Management, and Long term Outcomes 29. Models and Cellular Monolayers to Study the Effect of SARS CoV 2 on Kidneys 30. Clinical implications of COVID 19 in chronic kidney disease and end stage kidney disease Section 7: Long COVID 19 (long term effects summarizing of clinical reports in literature) Introduction 31. Long COVID or Post Acute Sequalae of COVID: An introduction 32. Long COVID: Pathophysiology and classification 33. Gender differences in Sequelae from COVID 19 Infection 34. Characterizing Long COVID 19: Lessons in the Clinic. 35. Implications of Long COVID for the Global Health Care System Section 8: The Vaccines Introduction 36. COVID 19: The Vaccine Development Strategies 37. mRNA vaccines: The New Frontier 38. Covid 19 vaccines: A Comprehensive review of Safety and Efficacy Section 9: Handling the Spread: Public Health and Social Measures Introduction 39. Lockdown measures during the COVID 19 pandemic 40. Efficacy of Facial masks against COVID 19 41. Vaccination Policies 42. Navigating the Impact of COVID 19 School Closures on Child Health, Education, and Society: A Call to Embrace Civil Discourse Across Identities, Sectors, and Disciplines 43. The Effect of the Pandemic on Care for Other Health Conditions 44. The role of smartphone assisted tools for Covid 19 diagnostic, treatment, and quarantine Section 10: From the Editors’ desk 45. What have we learnt from the COVID 19 pandemic?
Section 1: Coronaviruses (including SARS 1 and MERS), the Structure (sequence), Mechanism of Action Introduction 1. Origin, Evolution and Spread of SARS CoV 2 2. SARS CoV 2 Spike Proteins in Infectivity 3. Structural and functional properties of the SARS CoV 2 spike protein: potential vaccine and drug development for COVID 19 4. Population Specific Polymorphisms and SARS CoV 2 Infectivity 5. Insights into SARS CoV 2 Structure: Approaches and Action of SARS CoV 2 Main Protease Inhibitors 6. SARS CoV 2, SARS CoV, and MERS COV: Similarities and Differences in Origin and Transmission Section 2: Inflammation and Immune Response to SARS CoV 2 Introduction 7. Characterization of the Immune Response with Viral Attack 8. Inflammation, Cytokines and COVID 19 Severity 9. Immunological Considerations for COVID 19: Vaccines and Other Protective Strategies 10. Virus specific T cell response in SARS CoV 2 infection and vaccinations 11. Oral and Gut Inflammation and Microbiota with COVID 19 12. Implications of Inflammation: Bone and Joint Health with COVID 19 13. COVID 19 and immune dysfunction: Consequences, and natural remedies for management Section 3: Pathological Findings with Clinical Correlation Introduction 14. Pulmonary Pathology of Severe Covid 19 15. Histopathological Analysis of the Cardiovascular System in severe COVID 19 16. Postmortem Neuropathology in COVID 19 17. Renal Pathology in Severe Covid 19 Section 4: The Blood Vessels and COVID 19: Vascular Dysfunction and Coagulopathies Introduction 18. Vascular Manifestations of COVID 19: Endothelial Dysfunction and Damage 19. Immunothrombosis involvement in COVID 19 20. COVID 19 associated coagulopathy 21. D dimer in systemic circulation and COVID 19 outcome 22. Hypercoagulability in COVID 19 Section 5: Neuro COVID 19 and its Long Term Implications Introduction 23. COVID and the Nervous System: Mechanisms and Consequences 24. Neuroinflammation: Unraveling Acute and Long COVID 19 Effects 25. Acute and Post acute Neurologic and Psychiatric Manifestations in COVID 19 26. Pediatric Neurological and Neuropsychiatric Manifestations of COVID 19 27. Understanding the Pandemic: Pathophysiology, Transmission, and Treatment of Covid 19 Section 6: Should Covid 19 Concern Nephrologists? Why and to What Extent?" Introduction 28. Acute Kidney Injury with COvid 19: Mechanisms, Management, and Long term Outcomes 29. Models and Cellular Monolayers to Study the Effect of SARS CoV 2 on Kidneys 30. Clinical implications of COVID 19 in chronic kidney disease and end stage kidney disease Section 7: Long COVID 19 (long term effects summarizing of clinical reports in literature) Introduction 31. Long COVID or Post Acute Sequalae of COVID: An introduction 32. Long COVID: Pathophysiology and classification 33. Gender differences in Sequelae from COVID 19 Infection 34. Characterizing Long COVID 19: Lessons in the Clinic. 35. Implications of Long COVID for the Global Health Care System Section 8: The Vaccines Introduction 36. COVID 19: The Vaccine Development Strategies 37. mRNA vaccines: The New Frontier 38. Covid 19 vaccines: A Comprehensive review of Safety and Efficacy Section 9: Handling the Spread: Public Health and Social Measures Introduction 39. Lockdown measures during the COVID 19 pandemic 40. Efficacy of Facial masks against COVID 19 41. Vaccination Policies 42. Navigating the Impact of COVID 19 School Closures on Child Health, Education, and Society: A Call to Embrace Civil Discourse Across Identities, Sectors, and Disciplines 43. The Effect of the Pandemic on Care for Other Health Conditions 44. The role of smartphone assisted tools for Covid 19 diagnostic, treatment, and quarantine Section 10: From the Editors’ desk 45. What have we learnt from the COVID 19 pandemic?
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