Vascular Complications in Human Disease (eBook, PDF)

Mechanisms and Consequences
Redaktion: Abraham, David; Coghlan, Gerry; Dashwood, Michael; Handler, Clive

• Format: PDF

Produktbeschreibung

Vascular disease provides a clear example of the inherent and practical relationship between basic science and clinical medicine. Basic science underpins the rationale of treatment and potential future therapeutic approaches; problems in clinical management often direct new lines of laboratory research. Progress in treatment cannot continue without this close collaboration and this book has been designed to review this fascinating collaborative field of medical science.

As part of this evolving collaboration, Vascular Complications of Human Disease: Mechanisms and Consequences reviews the study, pathogenesis, management and treatment of some of the most common vascular diseases. The book includes discussions of approaches to gene therapy and aspects of regenerative medicine plus also physiology and pathogenesis, surgical and pharmacologic treatment, and complications.

Clinical specialists caring for patients with any form of vascular disease must clearly understand the basic scientific rationale for disease pathogenesis. This book presents a cohesive review of our current understanding of the most important areas of clinical science and medicine in vascular disease and identifies areas for research in the future. It will be a useful reference for basic and clinical scientists, and clinical specialists in vascular surgery, cardiology, angiology, neurology and any discipline in which the vascular system plays a fundamental part in the disease process.

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Produktdetails

• Verlag: Springer London
• Seitenzahl: 258
• Erscheinungstermin: 14. Oktober 2008
• Englisch
• ISBN-13: 9781846289194
• Artikelnr.: 37360485

Autorenporträt

Professor Dame Carol Black DBE, PRCP, President of the Royal College of Physicians, Professor and Head Of Academic and Clinical Department of Rheumatology, The Royal Free Hospital and University College London, UK. Professor David Abraham PhD, Head of Research, Academic and Clinical Department of Rheumatology, The Royal Free Hospital and University College London, UK. Dr Gerry Coghlan MD, Consultant Cardiologist, Director of the Pulmonary Hypertension Unit, The Royal Free Hospital, London, UK. Dr Michael Dashwood, PhD, Senior Lecturer in Biochemistry, University College London, UK. Dr Christopher Denton, PhD, Senior Lecturer and Consultant Rheumatologist, The Royal Free Hospital and University College London, UK. Dr Clive Handler MD, Honorary Consultant, Pulmonary Hypertension Unit, The Royal Free Hospital, London, UK. All the authors are internationally respected and leading clinical and basic scientists and clinicians.

Inhaltsangabe

Therapy for Pulmonary Vascular Disease.- Nitric Oxide Axis in Cardio-Pulmonary Disease.- Endothelin Signalling in the Cardiomyocyte.- TGF-beta/BMP Signalling in Pulmonary Vascular Disease.- The Endothelin System in Chronic Kidney Disease.- Endothelial Activation in Inflammation.- Pathogenic Mediators of Vessel Sclerosis.- Control of Interstitial Fluid Homeostasis.- Vascular Complications of Systemic Sclerosis.- Therapeutic Options for Preventing Transplant-Related Progressive Renal and Vascular Injury.- Current State of Medical Therapies for Peripheral Vascular Disease.- Advantages of Harvesting the Saphenous Vein for Coronary Artery Bypass Surgery Using the "No- Touch" Technique.- Towards the Prevention of Vein Graft Failure.- Statins and Cholesterol.- Endothelin-1 Promoting Actions in the Growth and Angiogenesis of Solid Cancers.- Gene Therapy for Apolipoprotein A-I and HDL The Ultimate Treatment for Atherosclerosis?- Ets Family of Transcription Factors and Vascular System.- The Aortic Valve: From Function to Tissue Engineering.

Rezensionen

From the reviews:

"This book on vascular biology as it relates to common complications of vascular diseases is divided into six sections addressing vascular complications in the pulmonary, renal, and cardiac systems as well as transplanted organs. ... The book is aimed at both basic and clinical scientists as well as clinicians in several different specialties. ... the book is most valuable for research scientists. ... This is an excellent book for basic or clinical scientists ... ." (Audrey Rosinberg, Doody's Review Service, October, 2009)