Set in the Carolina Bible Belt, from the 1950s to the 1980s, the story explores the parallel lives of two friends, Claire and Francis, separated when young. After being trafficked through an abusive foster care system, Francis arrives at the home of Pastor Leroy and his wife, Fat Cow. Leroy leads an evangelical church of worshipers who test their faith by handling deadly serpents. Francis learns the trade of snake handling and when her life is threatened, strikes back with venom. Claire's life, by contrast, seems relatively normal. As a psychologist, she counsels in a State Penitentiary. However, when her life comes under attack, she also reverts to tried and true methods to protect herself and family. In a life-threatening climax, the two adult women join a force of revenge.
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