Viral Membrane Proteins: Structure, Function, and Drug Design (eBook, PDF)

Redaktion: Fischer, Wolfgang B.

• Format: PDF

Produktbeschreibung

Protein Reviews, a new book series from Springer, covers all aspects of protein investigations including protein chemistry, sequence, 3-D structure, biological activity, proteomics, methodology, and many more new and emerging topics.

Volume 1: Viral Membrane Proteins: Structure, Function and Drug Design

Edited by Wolfgang B. Fischer

This volume, written by renowned leaders in the field, summarizes the current structural and functional knowledge of membrane proteins encoded by viruses while addressing questions about the proteins as potential drug targets.

Early praise for this volume:

"We all know that you can't treat viral disease with drugs.....That was what all physicians and scientists were taught for decades with conviction but without enough experiments. Fortunately, we were taught wrong: rationally designed drugs are available that work well against influenza as Garman and Laver describe so well (with the help of Wen Yang Wu) in a fascinating chapter of this book. In fact, viral membrane proteins have a range of functions of great medical and biological importance, not so surprisingly if one understands that membrane proteins control a wide range of function because they are gatekeepers for cells. Membrane proteins control entry into cells and viruses.

Viral Membrane Proteins" is a wonderful description of some of these proteins. The authors and editor are to be congratulated on producing much more than a collection of reviews and essays.

This book can help teach everyone that it is possible to treat viral disease with drugs that bind to membrane proteins. Knowing that, we can hope that more resources will be focused on finding other such drugs to the remaining scourges of mankind, at least those we do not produce ourselves."

- Robert S. Eisenberg, Rush University Medical Center, Chicago, IL

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 292
• Erscheinungstermin: 2. August 2007
• Englisch
• ISBN-13: 9780387281469
• Artikelnr.: 43731333

Inhaltsangabe

Membrane Proteins from Plant Viruses.- Membrane Proteins in Plant Viruses.- Structure and Function of a Viral Encoded K+ Channel.- Fusion Proteins.- HIV gp41: A Viral Membrane Fusion Machine.- Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination.- Aspects of the Fusogenic Activity of Influenza Hemagglutinin Peptides by Molecular Dynamics Simulations.- Viral Ion Channels/viroporins.- Viral Proteins that Enhance Membrane Permeability.- FTIR Studies of Viral Ion Channels.- The M2 Proteins of Influenza A and B Viruses are Single-Pass Proton Channels.- Influenza A Virus M2 Protein: Proton Selectivity of the Ion Channel, Cytotoxicity, and a Hypothesis on Peripheral Raft Association and Virus Budding.- Computer Simulations of Proton Transport Through the M2 Channel of the Influenza A Virus.- Structure and Function of Vpu from HIV-1.- Structure, Phosphorylation, and Biological Function of the HIV-1 Specific Virus Protein U (Vpu).- Solid-State NMR Investigations of Vpu Structural Domains in Oriented Phospholipid Bilayers: Interactions and Alignment.- Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1.- Virus Ion Channels Formed by Vpu of HIV-1, the 6K Protein of Alphaviruses and NB of Influenza B Virus.- The Alphavirus 6K Protein.- Membrane-Spanning/Membrane Associated.- The Structure, Function, and Inhibition of Influenza Virus Neuraminidase.- Interaction of HIV-1 Nef with Human CD4 and Lck.