Viral Molecular Machines (eBook, PDF)

Redaktion: Rossmann, Michael G.; Rao, Venigalla B.

• Format: PDF

Produktbeschreibung

A biological organism can be viewed as a collection of molecular machines well integrated to function as a self-replicating unit. One of the principal goals in biology is to be able to fully understand the mechanisms of an organism in atomic detail. Viruses offer the best opportunities to achieve this goal. Written by leaders in the respective fields, this book examines a variety of viral molecular machines, using the best examples from bacteriophages and animal viruses, many causing infectious diseases of public health importance. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, assembly of structural components, genome packaging and maturation into an infectious virion. The book conveys the state of the art knowledge of the topic generated by combining X-ray crystallography, high resolution electron microscopy, molecular genetics, biochemistry, and single molecule biophysics. Viral Molecular Machines is not only a "must-have" book for virologists but it will also be broadly useful for molecular biologists in academia and industry as well as an educational tool for teaching graduate and upper level undergraduate students.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Springer US
• Seitenzahl: 687
• Erscheinungstermin: 2. Februar 2012
• Englisch
• ISBN-13: 9781461409809
• Artikelnr.: 37350700

Inhaltsangabe

INTRODUCTION.- What are the machines in the life cycle of a virus?.-MOLECULAR MACHINES.- Beef F0 proton pump ATPase.- Flagella.- VIRUS ARCHETECTURE AND STRUCTURE.- Principles.-METHODS OF VIRAL ENTRY.- Polioviruses.- Alphaviruses.- Fusion type 1.- Flu.- HIV.- corona.- Fusion type 2.- Function of the tails for bacteriophages.- contractile (Petr Leiman.- non-contractile-long.- non-contractile-short.- GENOME REPLICATION.- Bunyaviruses.- Reoviruses.- DNA dependent, RNA dependent DNA and RNA polymerases.- CAPSID ASSEMBLY AND MATURATION.- Protein folding: chaperones.- Scaffolding proteins.- pH, proteolysis, metal ions, temperature as driving forces for assembly.- HK97 head maturation.- PRD1 assembly.- Herpes.- Adenovirus.- Large dsDNA viruses.- GENOME PACKAGING.- genome organization.- dsRNA viruses.- dsDNA packaging.- phi29 DNA packaging.- RNA packaging.- helical viruses.-