Helmut Vorbrüggen, Carmen Ruh-Pohlenz

Handbook of Nucleoside Synthesis

• Broschiertes Buch

Produktbeschreibung

A comprehensive survey of established and experimental methods in nucleoside synthesis This volume presents a comprehensive review of nucleoside synthesis with a uniquely broad perspective. It describes the three principal types of nucleoside-forming reactions-the fusion reaction, the metal salt procedure, and the Hilbert-Johnson reaction-as well as a number of other methods, and presents a broad overview of alternative chemical methods for synthesis. This comprehensive discussion includes a survey of experimental protocols for nucleoside synthesis, instructions on preparing components for the reaction, and a sampling of precise experimental procedures for the Vorbrüggen glycosylation reaction. Protocols for a variety of Lewis acid catalysts and carbohydrate precursors are also provided. An exhaustive tabular survey of glycosylation reactions with nucleobases covers approximately twenty years of literature. These tables are designed for quick visual inspection and form a primary literature resource for researchers in the discipline. Handbook of Nucleoside Synthesis is an essential resource for those working in nucleosides and oligonucleotides. This thoughtful and well-organized volume includes over 1,400 references that serve the knowledgeable researcher's every need. Those just entering the field will find it to be an indispensable survey of the experimental aspects of nucleoside synthesis.

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Produktdetails

• Verlag: Wiley
• Seitenzahl: 646
• Erscheinungstermin: 3. August 2001
• Englisch
• Abmessung: 229mm x 152mm x 38mm
• Gewicht: 1036g
• ISBN-13: 9780471093831
• ISBN-10: 0471093831
• Artikelnr.: 22343604

Autorenporträt

HELMUT VORBRUGGEN is Professor of Chemistry at the Free University in Berlin, Germany. CARMEN RUH-POHLENZ is Research Scientist at Schering AG in Berlin, Germany.

Inhaltsangabe

Foreword.
Preface.
Acknowledgments.
Synthesis of Nucleosides.
Introduction.
Nucleoside Synthesis.
Silyl-Hilbert-Johnson Reaction in the Presence of Friedel-Crafts Catalysts.
Mechanism of Nucleoside Formation in the Presence of Friedel-Crafts
Catalysts.
Special Preparations.
Miscellaneous Methods.
Alternative Nucleoside-Forming Reactions.
Experimental Conditions.
Experimental Procedures.
Tabular Survey.
References.
Index.