Carrie R. Jonak, Allison R. Peterson, Devin K. Binder

Posttraumatic Epilepsy

Basic and Clinical Aspects

• Broschiertes Buch

Produktbeschreibung

Posttraumatic Epilepsy: Basic and Clinical Aspects provides a synthesized resource on the recent basic and clinical science developments in the field of posttraumatic epilepsy. This book provides a clear understanding of the history of studies and epidemiology of posttraumatic epilepsy after head injury. The book also considers the neuropathology of posttraumatic epilepsy and clinical trials of antiepileptogenic agents evaluated after traumatic brain injury. The book covers the basic science of animal models of traumatic brain injury and the necessary and sufficient changes that must occur to generate epilepsy after head trauma. The authors explore potential mechanisms and novel therapeutic approaches to prevent posttraumatic epilepsy. The book is written for basic and clinical researchers in neuroscience as well as for clinicians treating patients with epilepsy.

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Produktdetails

• Verlag: Academic Press / Elsevier Science & Technology
• Artikelnr. des Verlages: C2020-0-03429-8
• Seitenzahl: 200
• Erscheinungstermin: 24. Oktober 2022
• Englisch
• Abmessung: 229mm x 504mm x 19mm
• Gewicht: 320g
• ISBN-13: 9780323900997
• ISBN-10: 0323900992
• Artikelnr.: 63564816

Autorenporträt

Carrie R. Jonak (research associate) is a neuroscience researcher in Dr. Binder's laboratory, in the Division of Biomedical Sciences at the University of California, Riverside.

Inhaltsangabe

1. History of posttraumatic epilepsy 2. Epidemiology of posttraumatic epilepsy 3. Neuropathology of posttraumatic epilepsy 4. Clinical trials of agents to prevent posttraumatic epilepsy 5. Surgical treatment of posttraumatic epilepsy 6. Animal models of traumatic brain injury 7. Incidence of posttraumatic epilepsy in animal models of traumatic brain injury 8. Cellular and molecular changes in animal models of posttraumatic epilepsy 9. Blood-brain barrier disruption and posttraumatic epilepsy 10. Inflammation and posttraumatic epilepsy 11. Biomarkers and treatment trials in animal models to prevent posttraumatic epilepsy 12. Therapeutic targets and future directions

Rezensionen

"With this comprehensive summary of the important animal model studies to date, the authors demonstrate that continued PTE research in humans is essential. It is crucial to know how to optimize PTE animal models and conduct detailed electrophysiological, cellular, and molecular analyses of PTE versus non-PTE brains in humans. Such future studies will help to identify more selective and precise therapies to treat PTE. We congratulate the authors for presenting this most comprehensive review of PTE from both basic science and clinical perspectives." --Journal of Neurosurgery